… of these diseases and how epigenetic changes can affect the severity of this … SENP1 leads
to an accumulation of HDAC4 on the MMP-1 promoter and decrease of MMP-1 expression…

… RA-FLSs was characterized by high expression levels of SUMO-1 and MMP-1, and low
expression levels of SENP1… the up-regulated SENP5 or SENP7, or down-regulated SENP1, they …

… are also considered epigenetic regulatory mechanisms. … of MMP-1 and SUMO-1 and also
low expression of SENP1 (… of SENP1 showed a decreased acetylation of H4 in the MMP-1 …

… abnormal expression of non-coding RNAs associated with RA … Epigenetic mechanisms
regulate chromatin structure and … marks as well as the abundance of MMP-1, MMP-3, MMP-9, …

… SUMOylation is also implicated in the epigenetic regulation of osteogenesis. In human dental
… SENP1 attenuates rheumatoid arthritis by suppressing MMP1 expression. SUMOylation of …

… SUMOylation is also implicated in the epigenetic regulation of … Rheumatoid arthritis (RA) is
a chronic systemic, inflammatory … in RA comes from the finding that expression of the SENP1 …

… as MMP-1 and MMP-3 expression in RA FLSs. We also demonstrated that SUMO-1 regulated
… SUMO 2/3 is involved in regulation of MMP-3 and MMP-13 [8] SENP1, which served as a …

… In line with these reports, the expression of the SENP1 desumoylase is decreased in RA …
Epigenetics and rheumatoid arthritis: the role of SENP1 in the regulation of MMP-1 expression. …

… in rheumatoid arthritis (RA). Increased glycolysis in … deacetylase 4 on the MMP-1 promoter,
inhibiting MMP-1 levels (20). … expression of p-PKM2 in FLSs and ST from patients with RA. …

… Lamin B1 deficiency has been associated with epigenetic as … the ECM-degrading proteins,
MMP-1 and MMP-13, which led … that Piezo1 might control SENP1 expression, carry out the de-…