… 3) show lack of any … coronary artery vasospasm, elevated resting blood pressures, and
sudden death. It was initially assumed that the presence of vasospasm and hypertension in SUR2 …

… GoF mutations in SUR2/Kir6.1-dependent K ATP channels, and the … Left heart disease can
lead to group 2 PH. Chronic left … Interestingly, coronary vasospasm has been reported in both …

… the SUR2 KATP channel is a crucial regulator of episodic … focal vasospasm even in the
absence of coronary disease on … may affect circulation and blood pressure, thereby increasing the …

… Episodic coronary artery vasospasm and hypertension develop in the absence of Sur2 K(ATP)
channels. J Clin Invest 2002; 110(2): 203-8. http://dx.doi.org/10.1172/JCI0215672 PMID: …

… that the reason for this lack of drug development may be due to … cardiomyocyte K ATP
channels via affinity to TMD2 on SUR2 [… K ATP channel openers for the treatment of hypertension …

… We recently developed murine CS models in which disease-… response to VSM K ATP channel
GoF, we crossed CS (SUR2 wt/… Glibenclamide-induced correction of low blood pressure in …

… the mean heart rate and arterial blood pressure are decreased… Similarly, episodic coronary
hypoperfusion such as CAS may … Furthermore, CMD can occur in the absence or presence of …

… the opening of K ATP channels reduces blood pressure and can … with the development of
functional changes of the heart in … and coronary spasms in animals [28, 30]. Low expression of …

… open probability in excised patches in the absence of Mg 2+ -… Kir6.1 and SUR2-containing
K ATP channels converged in a … hypertension in CS appears paradoxical, as K ATP channel …

… Also, in research on SUR2-null mice, a coronary artery vascular spasm … mice showed that
VSMC K ATP currents were absent in Kir6.1−/− mice, resulting in a hypertensive phenotype [51]…