… As in other RNA viruses, replication of RNA phages takes … A first distinction classifies epistasis
in magnitude epistasis, … on the studies carried out with φ6, the prototype RNA phage with a …

… investigating the evolution of RNA viruses that infect humans… to examine the effects of
epistasis on evolution. Burch and … of RNA viruses in disease emergence, a relationship between …

… functional relationship. Our results suggest that genotypes with similar epistatic interactions
… Here, we sought to investigate the relationship between the functional landscape of yeast (…

… effects and epistasis in general and as it pertains to the influenza virus, an RNA virus. … is
predicted for mutations in serial steps of a pathway, negative epistasis for mutations in related …

… Like other ‘winter’ RNA viruses, infections caused by the causative agent of COVID-19,
SARS-… Here we propose that many of these multiple driving forces are in ‘trade-off’ relationships …

… integration, and canalization can be coordinated. Concepts … (ie, evolvability) of the RNA
virus φ6 under thermal stress in … by an investigation of epistatic patterns and the underlying …

… To understand the relationship between robustness and evolvability, it is essential to know
that … epistasis shaped the function and evolution of an ancient transcription factor and its DNA …

… lytic RNA bacteriophage φ6 showed a positive correlation … represents a true example of
canalization, ie a system that … is a special example of epistasis and genetic interaction, we …