Esophageal Cancer Radiotherapy Dose Escalation Meta Regression Commentary: “High vs. Low Radiation Dose of Concurrent Chemoradiotherapy for Esophageal …
Discussion We commend the authors for a thorough and informative study that helps to
inform radiation dosing for non-operable patients. However, there exists heterogeneity in
their analyses that are worth commenting on and reanalyzing. This may or may not be
accounted for by the degree of dose escalation in individual studies. Specifically, the
magnitude of dose escalation may be an effect-modifier. To address this possible moderator
variable, we conducted a meta-regression of study results, as identified by Sun et al.(9) …
inform radiation dosing for non-operable patients. However, there exists heterogeneity in
their analyses that are worth commenting on and reanalyzing. This may or may not be
accounted for by the degree of dose escalation in individual studies. Specifically, the
magnitude of dose escalation may be an effect-modifier. To address this possible moderator
variable, we conducted a meta-regression of study results, as identified by Sun et al.(9) …
Discussion
We commend the authors for a thorough and informative study that helps to inform radiation dosing for non-operable patients. However, there exists heterogeneity in their analyses that are worth commenting on and reanalyzing. This may or may not be accounted for by the degree of dose escalation in individual studies. Specifically, the magnitude of dose escalation may be an effect-modifier. To address this possible moderator variable, we conducted a meta-regression of study results, as identified by Sun et al.(9). Meta-regression is a meta-analytic method that specifically accounts for possible confounders to reveal the true effect of the variables of interest.
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