[HTML][HTML] Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis

P Bayati, M Taherian, M Soleimani, H Farajifard… - Stem Cell Research & …, 2023 - Springer
… catenin and lymphoid enhancer factor [LEF]/T-cell factor [TCF]) [… of the key genes of the Wnt
signaling pathway and BMP4 in … signaling pathway genes were upregulated in the bleomycin-…

Inhibition of the stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease

…, SL Kunkel, M Phillips, C Hogaboam… - … -Lung Cellular and …, 2020 - journals.physiology.org
pulmonary diseases (including IPF), may be central to preserve important homeostatic functions
… SCF isoform expressed in the fibrotic lungs of bleomycin-treated mice and in fibroblasts …

[HTML][HTML] Enhanced secretion of hepatocyte growth factor in human umbilical cord mesenchymal stem cells ameliorates pulmonary fibrosis induced by bleomycin in rats

H Chen, Y Luo, Y Zhu, Y Ye, D Chen, X Song… - Frontiers in …, 2023 - frontiersin.org
… The data showed that the transcriptional level of HGF was relatively higher than that of other
significantly different genes, which suggested that HGF may play the main role in inhibiting …

The anti-fibrotic and anti-inflammatory potential of bone marrow–derived mesenchymal stem cells and nintedanib in bleomycin-induced lung fibrosis in rats

ES Gad, AAA Salama, MF El-Shafie, HMM Arafa… - Inflammation, 2020 - Springer
… is considered the master signaling pathway. Nintedanib and … Inhibition of these enzymes is
suggested to have a vital role … for the treatment of bleomycin-induced pulmonary fibrosis [27, …

[HTML][HTML] Protein kinase C δ (PKCδ) attenuates bleomycin induced pulmonary fibrosis via inhibiting NF-κB signaling pathway

J Wang, L Sun, Y Nie, S Duan, T Zhang… - Frontiers in …, 2020 - frontiersin.org
… defined an important role for PKCδ in BLM-induced pulmonary fibrosis and inflammation.
We demonstrated that PKCδ inhibits the activation of the NF-κB signal pathway by binding and …

[HTML][HTML] Adipose-derived mesenchymal stem cell therapy for reverse bleomycin-induced experimental pulmonary fibrosis

X Zhao, J Wu, R Yuan, Y Li, Q Yang, B Wu, X Zhai… - Scientific Reports, 2023 - nature.com
… TGF-β1/Smad signaling pathway to inhibit the TGF-β1-induced fibroblast … pulmonary fibrosis
14 . Research findings indicate that stem cells play an important role in repairing pulmonary

[HTML][HTML] … activation inhibits the protective effect of BM‑MSCs on bleomycininduced lung epithelial cell damage by inhibiting ERK signaling and the paracrine factor …

X Peng, X Li, C Li, S Yue, Y Huang… - International …, 2019 - spandidos-publications.com
… The hepatocyte growth factor (HGF) serves an important role … -MSC transplantation on
bleomycin (BLM)-induced pulmonary fibrosis in … signal-regulated kinase (ERK) signaling pathway. …

Inhibition of the Stem cell factor 248 isoform attenuates the development of pulmonary remodeling disease 2

W Lukacs - journals.physiology.org
… fibrotic pulmonary diseases (including IPF), may be central to … of SCF isoforms during bleomycin
induced 131 lung fibrosis … Raf-1/p44/42 signaling pathway. The American journal of 629 …

Induced Pluripotent stem-cells inhibit experimental bleomycin-induced pulmonary fibrosis through regulation of the insulin-like growth factor signaling

P Bayati, M Taherian… - … , Asthma and …, 2022 - publish.kne-publishing.com
… -like growth factor (Igf) signaling as a major contributor to IPF … the role of insulin-like growth
factor (IGF) signaling in the … the IGF signaling pathway, along with other signalling pathways, …

[HTML][HTML] … mesenchymal stem cells attenuate lung inflammation and fibrosis in the bleomycin-induced pulmonary fibrosis rat model via caveolin-1/NF-κB signaling axis

C Zhe, R Bingqing, L Guangyan, LIN Wei - Physiological Research, 2022 - ncbi.nlm.nih.gov
signaling pathway in the lungs of the bleomycin-induced PF model rats. In conclusion, this
study demonstrated that the ADMSCs protected against bleomycin-induced … plays a key role in …