Sex differences in ischemia/reperfusion injury: the role of mitochondrial permeability transition

JA Fels, G Manfredi - Neurochemical research, 2019 - Springer
… In addition to estradiol, estrogen receptors (ERs) are also … [29], and estradiol mediates
protection of ischemic male hearts … MPT are likely linked to the sexual dimorphism seen in IS/MI. …

[HTML][HTML] Non-genomic effects of estrogen on cell homeostasis and remodeling with special focus on cardiac ischemia/reperfusion injury

R Puglisi, G Mattia, A Carè, G Marano… - Frontiers in …, 2019 - frontiersin.org
… As a matter of fact both estrogen receptors are composed by six … More recently, the central
role of estrogen-mediated plasma … could exhibit a marked sexual dimorphism and that their …

Sex differences in renal ischemia-reperfusion injury

A Hosszu, A Fekete, AJ Szabo - American Journal of …, 2020 - journals.physiology.org
… experimental data demonstrate sexual differences in renal … a β-subunit, where the α-subunit
mediates catalytic activity (42). … relation to sex differences, we propose an estrogen receptor-…

Sex differences in cardiac ischemia/reperfusion injury

B Ostadal, P Ostadal, J Neckar - Sex Differences in Heart Disease, 2020 - Springer
… Most of the cardioprotective effects of estrogen are considered to be mediated through
the nuclear hormone receptors as well as through estrogen receptor (ER)-α or ER-β [60]. …

Heart Ischemia/Reperfusion Injury—Is the Female Equally Protected Compared to Male?

D Baetz, M Vedere - Biology of Women's Heart Health, 2023 - Springer
… discovered genes that exhibited sexual dimorphism [8]. … the differences observed in Ca 2+
handling may be mediated in … Some studies showed that beta estrogen receptor play a role in …

[HTML][HTML] Estradiol ameliorates acute kidney ischemia-reperfusion injury by inhibiting the TGF-βRI-SMAD pathway

L Ren, F Li, Z Di, Y Xiong, S Zhang, Q Ma… - Frontiers in …, 2022 - frontiersin.org
… Such effects are mainly mediated by estrogen receptors (ERα and ERβ) or G protein-coupled
ER (GPER) through genomic or nongenomic mechanisms (20). Analysis of kidney …

[HTML][HTML] Estrogen inhibits endoplasmic reticulum stress and ameliorates myocardial ischemia/reperfusion injury in rats by upregulating SERCA2a

J Chen, Y Liu, D Pan, T Xu, Y Luo, W Wu, P Wu… - Cell Communication and …, 2022 - Springer
… There are dramatic gender differences in the incidence of CHD [2]; the prevalence of CHD
in … actions of estrogen are mediated by classic nuclear estrogen receptors alpha and beta (…

[HTML][HTML] Sex Differences in Therapies against Myocardial Ischemia-Reperfusion Injury: From Basic Science to Clinical Perspectives

L Medzikovic, T Azem, W Sun, P Rejali, L Esdin… - Cells, 2023 - mdpi.com
estrogen (17β-estradiol; E2), may regulate myocardial IRI. E2 exerts genomic actions by
binding the classical estrogen receptors … of PAI-1 in an ER-mediated manner in vascular smooth …

Sex difference in the tolerance of hepatic ischemia-reperfusion injury and hepatic estrogen receptor expression according to age and macrosteatosis in healthy living …

S Han, J Cho, W Wi, KW Lee, HH Cha, S Lee… - …, 2022 - journals.lww.com
injury and enhancing recovery in the liver. The effects of estrogen are mediated by its
specific receptor… A significant gender difference was that donation age was greater in female …

Sirtuin-3 mediates sex differences in kidney ischemia-reperfusion injury

H Shen, M Holliday, D Sheikh-Hamad, Q Li… - Translational …, 2021 - Elsevier
… Sirt3 may mediate sexual dimorphism in AKI using a bilateral kidney ischemia-reperfusion
injury (IRI… Estrogen receptors are expressed in mitochondria of various tissues, 22 and there is …