Paclitaxel's mechanistic and clinical effects on breast cancer

TM Abu Samaan, M Samec, A Liskova, P Kubatka… - Biomolecules, 2019 - mdpi.com
… focused on PTX, its evaluations in preclinical research and … of the HER2 (ERBB2) gene
that encodes a transmembrane … PTX causes cytoskeletal abnormalities in which microtubules …

PI3K inhibitors in breast cancer therapy

H Ellis, CX Ma - Current oncology reports, 2019 - Springer
… In this review, we will discuss the rationale for targeting PI3K/… common signaling abnormalities
observed in breast cancer, … breast cancer, irrespective of PIK3CA mutation status (median …

Genetics and Oncology (part 2.). Fundamentals of personalised medicine in the treatment of breast and ovarian cancer

A Doraczyńska-Kowalik… - … Journal of Oncology, 2020 - journals.viamedica.pl
… of receptor tyrosine kinase erbB-2 gene (ERBB2 aka HER2). An … Furthermore, HER2 status
should be re-evaluated in post-… breast cancer, as well as for selected cases of specific-type …

The homologous recombination deficiency scar in advanced cancer: agnostic targeting of damaged DNA repair

V Pacheco-Barcia, A Muñoz, E Castro, AI Ballesteros… - Cancers, 2022 - mdpi.com
… In this review, we aim to summarize the roles of HRD across … trial evaluated PARPi efficacy
in early breast cancer after … excluded chromosome 17 because LOH on chromosome 17

Valproic acid and breast cancer: State of the art in 2021

A Wawruszak, M Halasa, E Okon, W Kukula-Koch… - Cancers, 2021 - mdpi.com
… This review focuses on in vitro and in vivo experimental data … status and level of development
of societies, cancer is one of … cancer cells without altering mRNAs levels of EGFR, ErbB2, …

Potential utility of telomere length assessment in breast cancer in a diagnostic histopathology setting.

PL Kong, LM Looi, PL Cheah - Malaysian Journal of …, 2023 - search.ebscohost.com
abnormalities that are non-cancerous and occurs more … variables of breast cancer (age,
histological grade, nodal status)… ERBB2 amplification in breast cancer analyzed by fluorescence …

DNA methylome in HER2-positive resistant breast cancer

S Palomeras Pairet - 2019 - dugi-doc.udg.edu
… Title: Dual fatty acid synthase and HER2 signaling blockade shows marked antitumor activity
against breast cancer models resistant to Anti-HER2 drugs. Authors: Adriana Blancafort, …

Molecularly targeted therapy towards genetic alterations in advanced bladder cancer

J Thomas, G Sonpavde - Cancers, 2022 - mdpi.com
… This review discusses the key targetable genetic aberrations and summarizes the … of ErbB2
inhibitors. They also noted that when compared to gastric and breast cancer, bladder cancer

Oncogenic signaling in tumorigenesis and applications of siRNA nanotherapeutics in breast cancer

NI Kamaruzman, NA Aziz, CL Poh, EH Chowdhury - Cancers, 2019 - mdpi.com
… In this review, we highlighted the effects of major signaling … ,5-trisphosphate, or the status of
intracellular Ca 2+ storage. It … that is encoded by ERBB2 gene. The transmembrane receptor …

Age-correlated protein and transcript expression in breast cancer and normal breast tissues is dominated by host endocrine effects

T Osako, H Lee, G Turashvili, D Chiu, S McKinney… - Nature Cancer, 2020 - nature.com
… their ER binding site status for the METABRIC expression … ER (ESR1) and HER2 (ERBB2)
subgroups for the METABRIC … this study was an assessment of genetic sources exhibiting age…