Cancer therapy guided by mutation tests: current status and perspectives

SN Aleksakhina, EN Imyanitov - International Journal of Molecular …, 2021 - mdpi.com
… The genomic examination of breast cancer includes testing … multiple copy number abnormalities
across the genome. The … aimed at evaluating the genome-wide status of chromosomal

Molecular Progression of Breast Cancer and Personalized Medicine in Terms of Clinical Trials

S Liaqat, M Hussain, K Aftab, M Khalid… - Breast Cancer: From …, 2022 - Springer
… For the practical implementation of personalized BC therapies, proper evaluation and … (erbB2)
belongs to the EGFR family of tyrosine kinases and is located on chromosome 17 (17q12). …

[PDF][PDF] Phase II study (KAMELEON) of single-agent T-DM1 in patients with HER2-positive advanced urothelial bladder cancer or pancreatic cancer …

J Rüschoff, M Lolkema, L GIANNI, E Voest, E de Vries… - 2023 - scientiasalut.gencat.cat
… 2 (HER2/ERBB2)– positive breast cancer. We aimed to study … and tumor response and to
evaluate biomarkers that could … , the HER2 gene, and chromosome 17 centromere (CEN17) in …

Gastric cancer, version 2.2022, NCCN clinical practice guidelines in oncology

JA Ajani, TA D'Amico, DJ Bentrem, J Chao… - … Comprehensive Cancer …, 2022 - jnccn.org
ERBB2 gene has been implicated in the development of gastric adenocarcinoma. However,
unlike in breast cancer, the prognostic significance of HER2 status in … is evaluated by IHC to …

Applications of artificial intelligence in breast pathology

Y Liu, D Han, AV Parwani, Z Li - Archives of pathology & …, 2023 - meridian.allenpress.com
… of low ERBB2 protein expression in breast cancer tissue. … The assessment of HER2 status
in breast cancer: the past, the … 2 (HER2) gene amplification in breast cancer specimens. Diagn …

A review of HER2 overexpression and somatic mutations in cancers

M Galogre, D Rodin, M Pyatnitskiy… - Critical Reviews in …, 2023 - Elsevier
… reducing cancer progression, which can be seen in breast cancer… for chromosome 17 copies
and cancers with more than one … , HER2 status in cancers can be tested in different cancers

Molecular Mechanisms of Early Breast Cancer

P Ariyannur, VK Srinivasalu - Management of Early Stage Breast Cancer …, 2021 - Springer
status, BRCA1/2 mutation status, ERBB2 amplification status) or … derangements in the long
arm of chromosome 17 [49, 50], … models for individualized risk assessment, and models that …

[HTML][HTML] Prognostic value of the PIK3CA, AKT, and PTEN mutations in oral squamous cell carcinoma: literature review

A Starzyńska, A Sejda, P Adamska… - Archives of Medical …, 2021 - ncbi.nlm.nih.gov
… PTEN protein loss, evaluated by measuring protein status by … Due to AKT gene activation
in many types of cancer and its … in various cancers, an analysis of AKT gene abnormalities in …

Exploring the contrasts: in-depth analysis of human and canine mammary tumors-discoveries at the frontier

LM Gherman, D Tomuleasa… - Medicine and …, 2024 - medpharmareports.com
abnormalities in human and canine samples to evaluate the canine model’s validity for breast
cancer … However, certain genes like TP53, EGFR, ERBB2, ATM and CHEK2 show lower …

Haploinsufficiency interactions between RALBP1 and p53 in ERBB2 and PyVT models of mouse mammary carcinogenesis

SP Singh, J Lee, C Bose, H Li, YC Yuan, A Hindle… - Cancers, 2021 - mdpi.com
… we evaluated the capacity of Rlip knockout to prevent breast … of genes related to breast
cancer by qRT-PCR in breast tumors … methylation abnormalities in the p53-null mice. That anti-…