… of the carboxylic acid moiety of 36 with a corresponding oxetan-3-ol (37) or thietan-3-ol (38) …
Preclinical characterization of acyl sulfonimidamides: Potential carboxylic acid bioisosteres …

… the systematic assessment of carboxylic acid bioisosteres of the … or when the design of
derivatives that do not enter the CNS is … The oxetan-3-ol and thietan-3-ol rings and corresponding …

… This review focuses on carboxylic acid bioisosteres that have emerged in the subsequent …
meable than carboxylic acid 114. In fact, the oxetan-3ol and thietan-3-ol derivatives displayed …

… bioisosteres in analog design, an assessment of the relative … possible bioisosteric relationships
of these derivatives have … in earlier SPR studies of carboxylic acid bioisosteres [26,41], …

… and evaluated to some extent versus carboxylic acids, … include the introduction of the carboxylic
acid, which reduced … at Roche on oxetanes as bioisosteres of gem-dimethyl and carbonyl …

… To circumvent this problem, in this study we evaluate model … phenylpropionic acid
derivatives bearing carboxylic acid … , B2), oxetan-3-ol (Y), thietane-3-ol (X1, X2), or acylurea (J) …

… and physicochemical evaluation of a series of N-acylsulfonamides and related bioisosteres.
The … of AII receptor antagonist carboxylic acid 1 and its tetrazole bioisostere, losartan 2. One …

… to medicinal chemistry were evaluated including carboxylic acids, … Additionally, 31 P NMR
binding data for carboxylic acid … This method has been used to evaluate the H-bond donating …

… Some studies suggest that carboxylic acid is key for binding, but it is also linked to gastrotoxicity.
In this sense, oxetan-3-ol and thietan-3-ol appear to be interesting bioisosteres in COX …

… to a carboxylic acid, was not burdened with an overt negative charge. This reflects a bioisosteric
… A comprehensive evaluation of the PK profile of 21 in preclinical species is compiled in …