[HTML][HTML] Evidence for monocyte reprogramming in a long-term postsepsis study
RB Gritte, T Souza-Siqueira, EB da Silva… - Critical Care …, 2022 - journals.lww.com
OBJECTIVES: This study sought to identify monocyte alterations from septic patients after
hospital discharge by evaluating gene expression of inflammatory mediators and monocyte
polarization markers. It was hypothesized that sepsis reprograms the inflammatory state of
monocytes, causing effects that persist after hospital discharge and influencing patient
outcomes. DESIGN: The gene expression patterns of inflammatory receptors, M1 and M2
macrophage polarization markers, NLRP3 inflammasome components, and pro-and anti …
hospital discharge by evaluating gene expression of inflammatory mediators and monocyte
polarization markers. It was hypothesized that sepsis reprograms the inflammatory state of
monocytes, causing effects that persist after hospital discharge and influencing patient
outcomes. DESIGN: The gene expression patterns of inflammatory receptors, M1 and M2
macrophage polarization markers, NLRP3 inflammasome components, and pro-and anti …
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