… mounting evidence for its important role in the DNA damage … that the p53 dimer is the
functional DNA-binding unit in vivo (35). … The damage-sensing ATM kinase plays both direct and …

… We found that a p53 mutant that cannot be phosphorylated … evidence that rapid recruitment
of p53 selectively required both … latency in vivo among various mutant p53 that correlated well …

… of this phosphorylation would affect p53 activity in vivo, we … in vivo response of S180A knock-in
mice to acute DNA damage, … Here, we provide evidence that DNA-binding cooperativity is …

… DNA damage-induced phosphorylation of MDM2 inhibits … These studies suggested the
possibility of a direct interaction … in vitro and in vivo analyses provided corroborating evidence …

… target gene analyses, there is evidence that they can … upon DNA binding 71 and robust p53
DNA binding in vitro in the … targets p53 for degradation, phosphorylation of p53 at the amino-…

… phosphorylation event in response to DNA damage. In conclusion, although AMPK is involved
in p53 Ser46 phosphorylation, experimental evidence for direct … p53 Ser46 residue in vivo …

… evidence for differential regulation of p53 by DNA damage … Both p53 phosphorylation on
Ser15 and protein stabilization … in the p53 DNA-binding domain in vitro and displayed p53-…

… m, In vitro binding of recombinant p53 with AKT1. … additional evidence for the functional
relevance of the p53–PIP n … phosphorylation of FOXO proteins mitigates DNA damage and …

… can be recapitulated by in vitro exogenous tau oligomer treatment in … the presence of DNA
damage, phosphorylated p53 is mislocalized … Here, for the first time, we report evidence of p53 …

… of mild DNA damage, p53 drives cell cycle arrest for DNA repair… Nonetheless, in vitro and
in vivo evidence has proven that … In contrast, phosphorylation, acetylation, neddylation, or …