Somatostatin, a presynaptic modulator of glutamatergic signal in the central nervous system

A Pittaluga, A Roggeri, G Vallarino… - International Journal of …, 2021 - mdpi.com
… innervating the septum, the striatum, the hippocampus and the … somatostatin immunoreactivity
was high, the sst2 receptorsevidence was published demonstrating that somatostatin

A role for the neuropeptide somatostatin in the neurobiology of behaviors associated with substances abuse and affective disorders

SL Robinson, TE Thiele - Neuropharmacology, 2020 - Elsevier
… We further summarize evidence of a direct role for the SST … observed in this study was
mediated by an increase in CeA SST … infusion increases striatal dopamine release via presynaptic …

Clinical significance of filamin A in patients with acromegaly and its association with somatostatin and dopamine receptor profiles

MCA Coelho, ML Vasquez, LE Wildemberg… - Scientific Reports, 2019 - nature.com
sst2 expression, sst5 expression, dopamine receptor subtype-2 (D2) expression, somatostatin
receptor … , where it acts as a key mediator of cytoskeleton reorganization 11 . FLNA binds …

Somatostatin and Neurotensin Systems in Schizophrenia

A Induni, F Gil Zbinden, MG López Ordieres - Psychiatry and Neuroscience …, 2021 - Springer
receptors mediate the inhibition of insulin secretion, and the sst2 receptor seems to mediate
… a culture of dopaminergic neurons, it has been enabled to prove a bidirectional interaction …

Somatostatin peptide signaling dampens cortical circuits and promotes exploratory behavior

DF Brockway, KR Griffith, CM Aloimonos, TT Clarity… - Cell reports, 2023 - cell.com
We sought to characterize the unique role of somatostatin (SST) in the prelimbic (PL) cortex
in mice. We performed slice electrophysiology in pyramidal and GABAergic neurons to …

Structure and Function of Somatostatin and its Receptors in Endocrinology

B Zhang, L Xue, ZB Wu - Endocrine Reviews, 2024 - academic.oup.com
… of currently 8 approved SST2 receptor ligands37. A subsequent … In contrast, cultured striatal
neurons exhibit constitutive D2R-… 13 lower affinities, more evidence is needed to support the …

Activation of dopamine D2 receptor promotes pepsinogen secretion by suppressing somatostatin release from the mouse gastric mucosa

XY Liu, LF Zheng, YY Fan, QY Shen… - … of Physiology-Cell …, 2022 - journals.physiology.org
… pepsinogen secretion directly through D1-like receptors on chief … D 2 R-mediated suppression
of somatostatin release. … brain striatum medium spiny neurons (81, 82) and the receptors

Molecular and cellular mechanisms underlying somatostatin-based signaling in two model neural networks, the retina and the hippocampus

M Cammalleri, P Bagnoli, A Bigiani - International journal of molecular …, 2019 - mdpi.com
… AMPA and kainate receptors mediate fast synaptic … support the notion that somatostatin, via
the SST 2 receptor, is able to … Definitive evidence for the role of somatostatin in inducing the …

Excitatory SST neurons in the medial paralemniscal nucleus control repetitive self-grooming and encode reward

J Sun, Y Yuan, X Wu, A Liu, J Wang, S Yang, B Liu… - Neuron, 2022 - cell.com
… Here, we identify that the excitatory somatostatin-positive neurons in the medial … activating
dopamine (DA) neurons in the ventral tegmental area (VTA) and eliciting dopamine release. …

Altered expression of somatostatin signaling molecules and clock genes in the hippocampus of subjects with substance use disorder

J Valeri, SM O'Donovan, W Wang, D Sinclair… - Frontiers in …, 2022 - frontiersin.org
… of somatostatin in subjects with substance use disorder and in subjects with major depression.
We also observed increased somatostatin receptor … first evidence for altered somatostatin