Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain

M Deng, SR Chen, HL Pan - Cellular and molecular life sciences, 2019 - Springer
excitatory neurotransmitter and facilitates fast excitatory synaptic transmission in the central
nervous system. The glutamate N-methyl-d-aspartate receptor … neonatal rat spinal cord slices …

Glutamate acts as a key neurotransmitter for itch in the mammalian spinal cord

QY Chen, M Zhuo - Molecular Pain, 2023 - journals.sagepub.com
… in the spinal cord are predominantly excitatory interneurons … of the amphibian 14-amino
acid peptide bombesin, isolated … pruriceptive nociceptors, most non-pruriceptive nociceptors

… spinal cord stimulation treatment attenuates the increase in spinal glutamate release and spinal miniature excitatory postsynaptic currents in rats with spared nerve …

WT Liao, CC Tseng, WT Chia, CR Lin - Brain Research Bulletin, 2020 - Elsevier
… 1; GLAST, glutamate/L-aspartate transporter; EAAC1, excitatory amino acid carrier 1. …
feedback of neurotransmitter release and altering the nociceptive transmission following SNI. …

Regional hyperexcitability and chronic neuropathic pain following spinal cord injury

J Kang, SS Cho, HY Kim, BH Lee, HJ Cho… - Cellular and molecular …, 2020 - Springer
… to nociceptive synaptic circuits within the injured spinal cord. … Following contusive SCI in
rats, DRG nociceptive neurons … Spinal dorsal horn neurons exhibit similar excitatory receptor/…

Serotonergic modulation of nociceptive circuits in spinal cord dorsal horn

R Bardoni - Current Neuropharmacology, 2019 - ingentaconnect.com
… neuron excitability and possibly neurotransmitter release. In … neurons, excitatory interneurons
expressing the receptor for … of norepinephrine, serotonin, and amino acids. J. Pharmacol. …

[HTML][HTML] Presynaptic NMDARs on spinal nociceptor terminals state-dependently modulate synaptic transmission and pain

RG Xie, WG Chu, DL Liu, X Wang, SB Ma… - Nature …, 2022 - nature.com
… -specific effects on neurotransmitter release and plasticity, ie … evoked excitatory postsynaptic
currents (eEPSCs) in spinal-… spinal cord remains to be fully explored. Here we generated …

Up‐regulation of astrocyte excitatory amino acid transporter 2 alleviates central sensitization in a rat model of chronic migraine

X Zhou, J Liang, J Wang, Z Fei, G Qin… - Journal of …, 2020 - Wiley Online Library
… oblongata to the first cervical cord were fixed overnight … excitatory effects on nociceptive
neurons along the trigeminovascular pathway, the role of glutamate as a pivotal neurotransmitter

Transmitter/receptor mechanisms in cardiovascular control by the NTS: excitatory amino acids, acetylcholine, and substance P

HN Sapru - Nucleus of the solitary tract, 2019 - taylorfrancis.com
… of the motor facial nucleus to the cervical cord. Rostrally, NTS is … and aortic baroreflexes
intact in the rat)8abolished all the … to the stimulation of nociceptive afferents. Nearly two dozen …

Presynaptic glutamate receptors in nociception

RG Xie, GY Xu, SX Wu, C Luo - Pharmacology & Therapeutics, 2023 - Elsevier
… Glutamate serves as the main excitatory neurotransmitter at key … nociceptive sensory signals
generated by nociceptors then leads to activation of secondary neurons in the spinal cord, …

[HTML][HTML] Spinal cord injury provoked neuropathic pain and spasticity, and their GABAergic connection

A Bhagwani, M Chopra, H Kumar - Neurospine, 2022 - ncbi.nlm.nih.gov
… helps balance the amino acid neurotransmitters GABA and glutamate… of the spinal cord limit
the spinal nociception by pre and … excessive release of excitatory amino acids like glutamate …