Increased α2δ‐1–NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy‐induced neuropathic pain
… The tissues from the dorsal half of the rat spinal cords were … To quantify the mechanical
nociceptive threshold in rats, we … of the probability of neurotransmitter release from the …
nociceptive threshold in rats, we … of the probability of neurotransmitter release from the …
NMDA Receptors at Primary Afferent–Excitatory Neuron Synapses Differentially Sustain Chemotherapy-and Nerve Trauma-Induced Chronic Pain
Y Huang, H Chen, D Jin, SR Chen… - Journal of …, 2023 - Soc Neuroscience
… NMDARs at the spinal cord level are … in the spinal cord are not interdependent in neuropathic
pain. This new information advances our mechanistic understanding of spinal nociceptive …
pain. This new information advances our mechanistic understanding of spinal nociceptive …
[HTML][HTML] The hypothalamic-spinal dopaminergic system: a target for pain modulation
M Puopolo - Neural regeneration research, 2019 - journals.lww.com
… by primary nociceptors to the dorsal horn of the spinal cord (DHSC)… express the aromatic
L-amino acid decarboxylase, the enzyme that … First, dopamine was found to inhibit the excitatory …
L-amino acid decarboxylase, the enzyme that … First, dopamine was found to inhibit the excitatory …
PKCγ interneurons, a gateway to pathological pain in the dorsal horn
A Artola, D Voisin, R Dallel - Journal of Neural Transmission, 2020 - Springer
… the nociceptive message to the dorsal horn of the spinal cord … Accordingly, excitatory glutamate
receptors are expressed by … -receptors in lamina I neurons of the spinal cord of adult rats. …
receptors are expressed by … -receptors in lamina I neurons of the spinal cord of adult rats. …
[HTML][HTML] The role of chemical transmitters in neuron-glia interaction and pain in sensory ganglion
Y Matsuka, S Afroz, JC Dalanon, T Iwasa… - Neuroscience & …, 2020 - Elsevier
… pain signalling due to neurotransmitter or cytokine release … one-half of C-type nociceptors.
CGRP is also expressed in … in the TG and upper cervical spinal cord. This increase in cytokine …
CGRP is also expressed in … in the TG and upper cervical spinal cord. This increase in cytokine …
[HTML][HTML] … of the effect of (S)-3, 4-Dicarboxyphenylglycine as a metabotropic glutamate receptors subtype 8 agonist on thermal nociception following central neuropathic …
… , up- or downregulation of neurotransmitters and their receptors, and … and their action can
be excitatory, increase glutamate-… an effect on spinal cord NMDA receptor activity. Therefore, …
be excitatory, increase glutamate-… an effect on spinal cord NMDA receptor activity. Therefore, …
Electroacupuncture Relieves CCI‐Induced Neuropathic Pain Involving Excitatory and Inhibitory Neurotransmitters
… increase the levels of GABA A receptor in spinal cord [17]. However, … NMDA receptors are
long-term defined as nociceptive … The limitation of the present study is that only six rats in each …
long-term defined as nociceptive … The limitation of the present study is that only six rats in each …
Astrocyte D-serine modulates the activation of neuronal NOS leading to the development of mechanical allodynia in peripheral neuropathy
SR Choi, DH Roh, SY Yoon, HS Choi… - Molecular …, 2019 - journals.sagepub.com
… D-serine degrading enzyme, D-amino acid oxidase (DAAO) … in the spinal cord dorsal horns
from the lumbar enlargement … of NMDA receptors leading to the sensitization of nociceptive …
from the lumbar enlargement … of NMDA receptors leading to the sensitization of nociceptive …
[HTML][HTML] P2X7 receptors exert a permissive effect on the activation of presynaptic AMPA receptors in rat trigeminal caudal nucleus glutamatergic nerve terminals
D Currò, P Navarra, I Samengo, M Martire - The Journal of Headache and …, 2020 - Springer
… CGRP causes sensitization of the nociceptive P2X3 receptors … In the spinal cord, the largest
AMPA receptor populations … the release of excitatory neurotransmitter and by facilitating the …
AMPA receptor populations … the release of excitatory neurotransmitter and by facilitating the …
[HTML][HTML] Glutamate receptors and glutamatergic signalling in the peripheral nerves
TJ Chen, M Kukley - Neural regeneration research, 2020 - journals.lww.com
… signalling only in the spinal cord but those were excluded … Transporter represents reversed
excitatory amino acid … Therefore, one can speculate that if nociceptive axons are capable of …
excitatory amino acid … Therefore, one can speculate that if nociceptive axons are capable of …