Bacteriophages Combined With Subtherapeutic Doses of Flucloxacillin Act Synergistically Against Staphylococcus aureus Experimental Infective Endocarditis

J Save, YA Que, JM Entenza, C Kolenda… - Journal of the …, 2022 - Am Heart Assoc
… Recently, using a model of experimental infective endocarditis (EE), we observed that
phage therapy alone was as effective as ciprofloxacin alone for the treatment Pseudomonas …

Type IV pili of Streptococcus sanguinis contribute to pathogenesis in experimental infective endocarditis

AM Martini, BS Moricz, LJ Woods… - Microbiology …, 2021 - Am Soc Microbiol
… steps in bacterial endocarditis. We recently used these types of experiments to identify S. …
For these experiments, we compared SK36 as the wild-type parent strain and the isogenic …

A review of current treatment strategies for infective endocarditis

D Luque Paz, I Lakbar, P Tattevin - Expert Review of Anti-infective …, 2021 - Taylor & Francis
… review to the anti-infective treatment of the main bacteria responsible for infective endocarditis,
ie … Principles of antibacterial treatment for infective endocarditis: from experimental data to …

[HTML][HTML] All Staphylococcus aureus bacteraemia-inducing strains can cause infective endocarditis: Results of GWAS and experimental animal studies

S Bastien, S Meyers, W Salgado-Pabón, SG Giulieri… - Journal of Infection, 2023 - Elsevier
… Mice model of infective endocarditis … In a first experiment, we tested whether bacteraemia
and endocarditis strains adhered differently to histamine-inflamed aortic valves. The vegetation …

[HTML][HTML] Anti-biofilm approach in infective endocarditis exposes new treatment strategies for improved outcome

CJ Lerche, F Schwartz, M Theut, EL Fosbøl… - Frontiers in Cell and …, 2021 - frontiersin.org
… The history of the experimental model of endocarditis dates to 1878 where Dr. Ottomar
Rosenbach was the pioneer to establish the principal of mechanically induced lesions of the …

Antistaphylococcal penicillins vs. cefazolin in the treatment of methicillin-susceptible Staphylococcus aureus infective endocarditis: a quasi-experimental monocentre …

B Lefèvre, B Hoen, F Goehringer, WN Sime… - European Journal of …, 2021 - Springer
… ) infective endocarditis (IE) is still debated in the absence of a randomized controlled trial.
In this quasi-experimental study, … In this quasi-experimental, effectiveness and safety did not …

[HTML][HTML] Coagulation: At the heart of infective endocarditis

L Liesenborghs, S Meyers, T Vanassche… - Journal of Thrombosis …, 2020 - Elsevier
… A heart valve infection or infective endocarditis is an enigmatic disease that continues to …
If bacteria are injected, these lesions evolve to experimental infective endocarditis lesions …

Host-pathogen interactions of clinical S. aureus isolates to induce infective endocarditis

C Schwarz, Y Töre, V Hoesker, S Ameling, K Grün… - Virulence, 2021 - Taylor & Francis
… In preparation for the infection experiments bacteria from overnight culture in Tryptic Soy
Broth (TSB) (shaking conditions, 37 C) were adjusted to OD 578 0.1 in TSB. After 3 h of growth (…

[HTML][HTML] Isolating crucial steps in induction of infective endocarditis with preclinical modeling of host pathogen interaction

C Schwarz, V Hoerr, Y Töre, V Hösker… - Frontiers in …, 2020 - frontiersin.org
… Aortic valves were removed from each experimental group 24 h post infection and analyzed
by transmission electron microscopy (TEM). In brief, heart valves or catheters were fixed in 2…

[HTML][HTML] … Doses of Vancomycin Synergize with Bacteriophages for Treatment of Experimental Methicillin-Resistant Staphylococcus aureus Infective Endocarditis

J Save, YA Que, J Entenza, G Resch - Viruses, 2022 - mdpi.com
Background. Recurrent therapeutic failures reported for the treatment of methicillin-resistant
Staphylococcus aureus (MRSA) infective endocarditis (IE) with vancomycin may be due to …