… In the developing mouse embryo, ShcD is present throughout the CNS, as … in expression
patterns and signaling properties likely promote non-redundant functions of Shc proteins within …

… ShcD, the focus of this thesis, is the most recently identified homolog from the Shc family
and thus remains the least well characterized (Fagiani et al., 2007; Jones et al., 2007). Its …

… ShcD (also known as SHC4) is a member of the Shc family of phosphotyrosine adaptor
proteins … multiple subtypes, each with distinct gene expression patterns (39). These consist of …

… Shc family proteins do share the modular domains however they have their unique expression
patterns … previously in this lab by screening a mouse embryo yeast two hybrid library. The …

… However, a comparison of the gene expression patterns … showed that ShcD was highly
expressed in murine cardiac … by the SHC gene family might be involved in the heart development …

… Both shc-3 and shc-1 are required for long-term survival in L1 arrest and survival in heat
stress… recognized role of Shc proteins, to function as an adapter for receptor tyrosine kinases. 15 …

… and ShcD. However, there have been no studies suggesting a role for Shc-family proteins in
… Therefore, the present study is the first to indicate an essential role of Shc-family proteins in …

… -in-mouse melanoma models … expression of an adaptor protein of the Shc family, ShcD, can
change the phenotype and the invasive properties of melanoma cells when highly expressed…

… SHC adaptor protein (SHCA) and lipoma-preferred partner (LPP) mediate transforming growth
… Reduced expression of either protein diminishes breast cancer lung metastasis, but the …

… collagen (Shc) family of adaptor proteins assists in … growth factor (TGF)β signalling plays
a major role in epithelial cell morphology changes and alterations in gene expression patterns …