Faster regeneration associated to high expression of Fam65b and Hdac6 in dysferlin-deficient mouse

R Ishiba, ALF Santos, CF Almeida, LC Caires… - Journal of Molecular …, 2019 - Springer
… remarkable regenerative capacity characterized by a faster … of muscle degeneration and
infiltration of mononuclear cells, … , the recovery from small strains is performed by myogenesis

[HTML][HTML] Dysferlin-deficiency has greater impact on function of slow muscles, compared with fast, in aged BLAJ mice

EM Lloyd, H Xu, RM Murphy, MD Grounds… - PLoS …, 2019 - journals.plos.org
… Dysferlinopathy is characterised by progressive skeletal … However, soleus post fatigue
recovery showed a significant … ] and ApoE null mice crossed with dysferlin null mice show striking …

On the role of dysferlin in striated muscle: membrane repair, t‐tubules and Ca2+ handling

CJ Quinn, EJ Cartwright, AW Trafford… - The Journal of …, 2024 - Wiley Online Library
… membrane repair mechanism in cultured human dysferlin-null myoblasts. However, the …
Extensive mononuclear infiltration and myogenesis characterize recovery of dysferlin-null

Minimally invasive muscle embedding generates donor-cell-derived muscle fibers that express desmin and dystrophin

JA Roche, M Begam, AK Eaton, CJ Elkins… - Military …, 2020 - academic.oup.com
… Roche JA, Lovering RM, Roche R, Ru LW, Reed PW, Bloch RJ: Extensive mononuclear
infiltration and myogenesis characterize recovery of dysferlin-null skeletal muscle from …

[HTML][HTML] Elevated Ca2+ at the triad junction underlies dysregulation of Ca2+ signaling in dysferlin-null skeletal muscle

V Lukyanenko, J Muriel, D Garman, L Breydo… - Frontiers in …, 2022 - frontiersin.org
… This should be sufficient to restore intracellular Ca 2+ to levels seen in wild type muscle. …
underlies dysregulation of Ca 2+ signaling in dysferlin-null myofibers, and that dysferlin’s C2A …

The contrasting roles of Dysferlin during tumor progression in renal cell carcinoma

A Cox, C Zhao, Y Tolkach, D Nettersheim… - … Oncology: Seminars and …, 2020 - Elsevier
… phospholipid-binding domains that are well characterized in the synaptotagmin family of
vesicle … Given the paucity of data, we performed a comprehensive analysis of DYSF mRNA and …

[图书][B] Enhancing membrane repair as a therapeutic strategy for various muscular dystrophies

TA Kwiatkowski - 2020 - search.proquest.com
… have been unsuccessful, in part due to the large size of the dysferlin gene. We find …
each other and with the plasma membrane to restore its integrity. An overview of the …

[HTML][HTML] From mice to humans: an overview of the potentials and limitations of current transgenic mouse models of major muscular dystrophies and congenital …

M Sztretye, L Szabó, N Dobrosi, J Fodor… - International Journal of …, 2020 - mdpi.com
… the diagnosis and extensive characterization of disease progression … necrosis, and cellular
infiltration can be histologically … The technique resulted in a promising functional restoration

Muscle xenografts reproduce key molecular features of facioscapulohumeral muscular dystrophy

AL Mueller, A O'Neill, TI Jones, A Llach, LA Rojas… - Experimental …, 2019 - Elsevier
… DAPI (blue) was used to label the nucleus of a mononuclear … ) X-irradiation to suppress
murine myogenesis and thereby to … Here, we describe a novel protein biomarker which is readily …

[HTML][HTML] Humanization of the mdx Mouse Phenotype for Duchenne Muscular Dystrophy Modeling: A Metabolic Perspective

G Donen, N Milad, P Bernatchez - Journal of Neuromuscular …, 2023 - content.iospress.com
… (MD) that is characterized by early muscle wasting and lethal … These mice show increased
number of myogenic cells, … 11 weeks, impaired force recovery with compromised sarcolemma …