… form of variation discussed in this Review has been point … involvement alongside increased
mutation frequency. As would … genetic diversity demonstrated in other studies of post-therapy …

… years to support non-Darwinian neutral evolution in tumours. In … On the other hand, genetically
and non-genetically diverse … an increased frequency of LOI of the IGF2 encoding gene in …

… The starting point of Case 1 is the WGS sequencing data from seven samples (labeled C0, …
is shown with a red dot even at a very low frequency). The remaining three subclones are all …

… high incidence of cancer in … a non-Darwinian type of evolutionary approach. Of note, other
mechanisms may also participate in cancer evolution since the degree of genetic diversity and …

… targeting cancer vulnerabilities arising from non-Darwinian patterns … population of genetically
diverse cells giving rise to distinct … Several pan-cancer studies revealed a high frequency of …

… developed countries, with the highest incidence of cases occurring in parts of … non-Darwinian
mechanics in hepatocellular carcinoma showed that the extremely high genetic diversity …

… in a better treatment, unless one manages to eradicate every single tumor cell. But the law
… Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian cell …

… Extremely high genetic diversity in a single tumor points to prevalence of non-Darwinian
cell evolution. Proc Natl Acad Sci USA, Nov 24; 112(47), E6496–505. doi: https://doi. …

… However, there are some points that must be clarified. … evolutionary trajectories within a
single tumor. For example, the … structure of genetically distinct subclones, very reminiscent of …

… both Darwinian and non-Darwinian patterns in cancer evolution. We … genome can lead
to genetic variability and diversification within … The incidence of multiple genetic and non-genetic …