[HTML][HTML] Fecal microbiota transplantation for the treatment of recurrent and severe Clostridium difficile infection in solid organ transplant recipients: a multicenter …
YW Cheng, E Phelps, V Ganapini, N Khan… - American Journal of …, 2019 - Elsevier
Fecal microbiota transplant (FMT) is recommended for Clostridium difficile infection (CDI)
treatment; however, use in solid organ transplantation (SOT) patients has theoretical safety
concerns. This multicenter, retrospective study evaluated FMT safety, effectiveness, and risk
factors for failure in SOT patients. Primary cure and overall cure were defined as resolution
of diarrhea or negative C difficile stool test after a single FMT or after subsequent FMT
(s)±anti-CDI antibiotics, respectively. Ninety-four SOT patients underwent FMT, 78% for …
treatment; however, use in solid organ transplantation (SOT) patients has theoretical safety
concerns. This multicenter, retrospective study evaluated FMT safety, effectiveness, and risk
factors for failure in SOT patients. Primary cure and overall cure were defined as resolution
of diarrhea or negative C difficile stool test after a single FMT or after subsequent FMT
(s)±anti-CDI antibiotics, respectively. Ninety-four SOT patients underwent FMT, 78% for …
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