Cancer-associated mutations but no cancer: insights into the early steps of carcinogenesis and implications for early cancer detection

SR Kennedy, Y Zhang, RA Risques - Trends in cancer, 2019 - cell.com
… somatic evolution, and are consistent with cancer as a multistep process. Precancerous cells
likely exist along a genetic continuum and only rarely culminate in clinically defined cancer. …

Identifying key questions in the ecology and evolution of cancer

AM Dujon, A Aktipis, C Alix‐Panabières… - Evolutionary …, 2021 - Wiley Online Library
… Thus, the interdisciplinary field of research, Ecology, Evolution and Cancer, is not only …
cancer evolution? Can we gain a better understanding of the clonal evolution of malignant cells

Spatial biology of cancer evolution

Z Seferbekova, A Lomakin, LR Yates… - Nature Reviews …, 2023 - nature.com
… enabling the nascent field of spatial cancer biology are … as in their sensitivity and available
field of view. Combining genomic, … on the spatial aspects of cancer evolution, summarize how …

Over a century of cancer research: Inconvenient truths and promising leads

C Sonnenschein, AM Soto - PLoS biology, 2020 - journals.plos.org
… at the root of the cancer puzzle while providing a … of carcinogenesis that is compatible with
evolutionary theory. In this essay, we explain how this new theory, the tissue organization field

The cheating cell: How evolution helps us understand and treat cancer

A Aktipis - 2020 - torrossa.com
… Then I moved to the University of Arizona to work as a postdoctoral researcher, and I began
working with John Pepper, a pioneer in cancer evolution, a new field at the time. I realized …

A generalized theory of age-dependent carcinogenesis

A Rozhok, J DeGregori - Elife, 2019 - elifesciences.org
about cancer drivers and stem cells. The MMC paradigm was later confirmed, and cancer
level tumor suppressive processes, and the evolution of group-specific cellular mechanisms …

The evolutionary history of 2,658 cancers

M Gerstung, C Jolly, I Leshchiner, SC Dentro… - Nature, 2020 - nature.com
… These inferences include timing of chromosomal gains during early somatic evolution 16 ,
phylogenetic analysis of late cancer evolution using matched primary and metastatic tumour …

[HTML][HTML] Magnetic fields and cancer: epidemiology, cellular biology, and theranostics

ME Maffei - International Journal of Molecular Sciences, 2022 - mdpi.com
… to potential health risks, being present in our planet before the evolution of living organisms;
… seven weeks was not carcinogenic nor cancer-promoting for colon carcinogenesis in male …

Genetic and non-genetic mechanisms underlying cancer evolution

Y Shlyakhtina, KL Moran, MM Portal - Cancers, 2021 - mdpi.com
… Although the linear tumour evolution model is one of the most accepted in the field, limited
… Organisation as a class I carcinogen that causes gastric cancer. Moreover, Fusobacterrium …

Reactive oxygen species: a volatile driver of field cancerization and metastasis

Z Liao, D Chua, NS Tan - Molecular cancer, 2019 - Springer
… molecules for field cancerization and metastasis. Field cancerization and metastasis are often
… In the late stages of tumor evolution, metastatic tumors developed mechanisms that exploit …
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