Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells
… of multiple fields of study, including aneuploidy, stem cell biology, genetic instability,
tumor … Traditionally, in the field of evolutionary biology, the preservation and occurrence of …
tumor … Traditionally, in the field of evolutionary biology, the preservation and occurrence of …
[HTML][HTML] Macrophages at the interface of the co-evolving cancer ecosystem
DJ Kloosterman, L Akkari - Cell, 2023 - cell.com
… genes solely governing tumor cell fitness. However, the oncology field now appreciates that
… of macrophages as a central force in driving cancer evolution. First, we give an overview of …
… of macrophages as a central force in driving cancer evolution. First, we give an overview of …
[HTML][HTML] The evolution of lung cancer and impact of subclonal selection in TRACERx
… cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher
lung cancer evolution … In lung adenocarcinoma, mutations in 22 out of 40 common cancer …
lung cancer evolution … In lung adenocarcinoma, mutations in 22 out of 40 common cancer …
The microbiome and human cancer
… the role of bacteria in carcinogenesis and cancer therapy. However, … Now the field is
encountering intriguing claims of the … a nuanced understanding of cancer-host-microbial evolution. …
encountering intriguing claims of the … a nuanced understanding of cancer-host-microbial evolution. …
Single-Cell RNA Sequencing Reveals the Cellular Origin and Evolution of Breast Cancer in BRCA1 Mutation Carriers
L Hu, L Su, H Cheng, C Mo, T Ouyang, J Li, T Wang… - Cancer research, 2021 - AACR
… The R package “pROC” was used to calculate the area under the ROC curve (AUC) of each
cell type… to construct a map of carcinogenesis for each BRCA1 mutation carrier (Fig. 4B). The …
cell type… to construct a map of carcinogenesis for each BRCA1 mutation carrier (Fig. 4B). The …
[HTML][HTML] The evolution of hematopoietic cells under cancer therapy
… and change the selective pressures in tissues, thus influencing their evolution. However, …
explore their influence on the evolution of hematopoietic cells. Cells of Acute Myeloid Leukemia …
explore their influence on the evolution of hematopoietic cells. Cells of Acute Myeloid Leukemia …
[HTML][HTML] Stem cells and origins of cancer in the upper gastrointestinal tract
Y Hayakawa, H Nakagawa, AK Rustgi, J Que… - Cell Stem Cell, 2021 - cell.com
… stem cells in metaplasia and early expansion of mutated stem-cell-derived clones during
carcinogenesis… development to better study gastroesophageal stem cells and advance the field. …
carcinogenesis… development to better study gastroesophageal stem cells and advance the field. …
[HTML][HTML] Genesis and mechanism of some cancer types and an overview on the role of diet and nutrition in cancer prevention
… Several carcinogenic and mutagenic constituents are present in our food [9,10]. There is …
in the field of cancer research. Carbohydrate intake has been hypothesized to modulate …
in the field of cancer research. Carbohydrate intake has been hypothesized to modulate …
[HTML][HTML] The role of HPV‑induced epigenetic changes in cervical carcinogenesis
MLR Da Silva, BHDR De Albuquerque… - Biomedical …, 2021 - spandidos-publications.com
… part of a natural evolutionary process of necessary adaptations to … with recognized knowledge
in the area were selected. … uncontrolled cell growth and proliferation of cancer cells (6,78). …
in the area were selected. … uncontrolled cell growth and proliferation of cancer cells (6,78). …
[HTML][HTML] The contribution of evolutionary game theory to understanding and treating cancer
B Wölfl, H Te Rietmole, M Salvioli… - Dynamic Games and …, 2022 - Springer
… We suggest that cancer progression is an evolutionary competition between different cell
types and … Compared to other fields of applied mathematics, EGT of cancer is a relatively new …
types and … Compared to other fields of applied mathematics, EGT of cancer is a relatively new …