Cancer recurrence and lethality are enabled by enhanced survival and reversible cell cycle arrest of polyaneuploid cells

KJ Pienta, EU Hammarlund, JS Brown… - Proceedings of the …, 2021 - National Acad Sciences
… of multiple fields of study, including aneuploidy, stem cell biology, genetic instability,
tumor … Traditionally, in the field of evolutionary biology, the preservation and occurrence of …

[HTML][HTML] Macrophages at the interface of the co-evolving cancer ecosystem

DJ Kloosterman, L Akkari - Cell, 2023 - cell.com
… genes solely governing tumor cell fitness. However, the oncology field now appreciates that
… of macrophages as a central force in driving cancer evolution. First, we give an overview of …

[HTML][HTML] The evolution of lung cancer and impact of subclonal selection in TRACERx

AM Frankell, M Dietzen, M Al Bakir, EL Lim, T Karasaki… - Nature, 2023 - nature.com
cell lung cancer prospectively enrolled into the TRACERx study. This project aims to decipher
lung cancer evolution … In lung adenocarcinoma, mutations in 22 out of 40 common cancer

The microbiome and human cancer

GD Sepich-Poore, L Zitvogel, R Straussman, J Hasty… - Science, 2021 - science.org
… the role of bacteria in carcinogenesis and cancer therapy. However, … Now the field is
encountering intriguing claims of the … a nuanced understanding of cancer-host-microbial evolution. …

Single-Cell RNA Sequencing Reveals the Cellular Origin and Evolution of Breast Cancer in BRCA1 Mutation Carriers

L Hu, L Su, H Cheng, C Mo, T Ouyang, J Li, T Wang… - Cancer research, 2021 - AACR
… The R package “pROC” was used to calculate the area under the ROC curve (AUC) of each
cell type… to construct a map of carcinogenesis for each BRCA1 mutation carrier (Fig. 4B). The …

[HTML][HTML] The evolution of hematopoietic cells under cancer therapy

O Pich, A Cortes-Bullich, F Muiños… - Nature …, 2021 - nature.com
… and change the selective pressures in tissues, thus influencing their evolution. However, …
explore their influence on the evolution of hematopoietic cells. Cells of Acute Myeloid Leukemia …

[HTML][HTML] Stem cells and origins of cancer in the upper gastrointestinal tract

Y Hayakawa, H Nakagawa, AK Rustgi, J Que… - Cell Stem Cell, 2021 - cell.com
… stem cells in metaplasia and early expansion of mutated stem-cell-derived clones during
carcinogenesis… development to better study gastroesophageal stem cells and advance the field. …

[HTML][HTML] Genesis and mechanism of some cancer types and an overview on the role of diet and nutrition in cancer prevention

N Kamal, MA Ilowefah, AR Hilles, NA Anua, T Awin… - Molecules, 2022 - mdpi.com
… Several carcinogenic and mutagenic constituents are present in our food [9,10]. There is …
in the field of cancer research. Carbohydrate intake has been hypothesized to modulate …

[HTML][HTML] The role of HPV‑induced epigenetic changes in cervical carcinogenesis

MLR Da Silva, BHDR De Albuquerque… - Biomedical …, 2021 - spandidos-publications.com
… part of a natural evolutionary process of necessary adaptations to … with recognized knowledge
in the area were selected. … uncontrolled cell growth and proliferation of cancer cells (6,78). …

[HTML][HTML] The contribution of evolutionary game theory to understanding and treating cancer

B Wölfl, H Te Rietmole, M Salvioli… - Dynamic Games and …, 2022 - Springer
… We suggest that cancer progression is an evolutionary competition between different cell
types and … Compared to other fields of applied mathematics, EGT of cancer is a relatively new …