… of the mechanisms behind pulmonary carcinogenesis. About 90 % of lung cancer cases are
… The second area of research that will have a significant impact on our understanding and …

… the mechanisms driving carcinogenesis and cancer progression … Cancer Cells may represent
a previously overlooked area of … benign stromal cells that can co-evolve with cancer cells to …

… steps of carcinogenesis and drug resistance, yet may render cancer cells more susceptible
… that will drive biological discovery and transform the field of cell and gene therapy. Here, we …

… for targeted cancer therapy, in particular, raising novel hypothesis or theory in this field on
the … ” to describe DNA damage repair pathway evolution, and “DNA damage baseline drift”, …

… of this rapidly evolving field, and the growing number of reported cancer cell-intrinsic features
that … in a mouse model of multistage pancreatic β-cell carcinogenesis resulted in vascular …

… cellular plasticity during cancer development, as has been shown to occur in cancer stem
cells, 32 … shifts during colorectal carcinogenesis and co-evolve with epithelial genetic events. …

… This field is evolving at a tremendous rate, and so, by the time of … to the cancer research
field directly. Knowledge is powerful. … We now appreciate that carcinogenesis is not just a cell…

… Evolutionary cancer cell … the field of carcinogenic and tumorigenic cancer cell biology [9–11,
13], is based on the recognition that human cancer represents a shift to a lower level of cell …

… expression in preinvasive disease and the exacerbation of cellular diversity by APOBEC3B
through DNA replication stress to promote chromosomal instability early in cancer evolution. …

… a role in cervical carcinogenesis, we generated a mouse model with cervical epithelial
cell-specific expression of … Note the invasion of cancer in the uterine and vaginal area (red arrow). …