[HTML][HTML] Trypanosoma cruzi infection in the wild Chagas disease vector, Mepraia spinolai: Parasitic load, discrete typing units, and blood meal sources

M Saavedra, A Bacigalupo, MV Barrera, MJ Vergara… - Acta Tropica, 2022 - Elsevier
… C/s, recording the changes in fluorescence with changes in … the parasitic load of naturally
infected Mepraia spinolai that … cruzi DTU composition - with TcII as single or mixed infection - …

Spatio-temporal characterization of Trypanosoma cruzi infection and discrete typing units infecting hosts and vectors from non-domestic foci of Chile

C Ihle-Soto, E Costoya, JP Correa… - PLoS Neglected …, 2019 - journals.plos.org
cruzi infection and DTU composition in mammals and … the natural clustering of the population
affected [39]. In the present study, we aimed to assess spatial and temporal variations of T. …

Serological approaches for Trypanosoma cruzi strain typing

V Balouz, L Bracco, AD Ricci, G Romer, F Agüero… - Trends in …, 2021 - cell.com
cruzi infection primarily occurs when humans are exposed to … six major evolutionary lineages
or discrete typing units (DTUs) (… genomic studies showing interstrain variations in the gene …

Elucidating diversity in the class composition of the minicircle hypervariable region of Trypanosoma cruzi: New perspectives on typing and kDNA inheritance

F Rusman, N Tomasini, NF Yapur… - PLoS Neglected …, 2019 - journals.plos.org
… phylogenetic lineages formally recognised as Discrete Typing Units (DTUs), TcI–TcVI [2, 3];
… -DTU variations in the number of clusters were observed in strains of TcI and TcII (Table 2). …

Differential tissue distribution of discrete typing units after drug combination therapy in experimental Trypanosoma cruzi mixed infection

M Strauss, MSL Presti, JC Ramírez, PC Bazán… - Parasitology, 2021 - cambridge.org
… CLO), in mice infected with Trypanosoma cruzi, Casibla isolate which consists of a mixture
of two discrete typing units (DTUs). Albino Swiss mice were infected and treated with high and …

Intra-host Trypanosoma cruzi strain dynamics shape disease progression: the missing link in Chagas disease pathogenesis

E Dumonteil, H Desale, W Tu… - Microbiology …, 2023 - Am Soc Microbiol
… a 2.5-year period in naturally infected rhesus macaques. … a lesser role than DTU composition
in determining parasite … detected important individual variations in changes in parasitemia …

[HTML][HTML] Deep sequencing reveals multiclonality and new discrete typing units of Trypanosoma cruzi in rodents from the southern United States

H Pronovost, AC Peterson, BG Chavez, MJ Blum… - … and Infection, 2020 - Elsevier
… DTU composition varied according to the tissue analyzed. Rural and urban rodents carried
… found to be naturally infected with T. cruzi 6 and some (including Triatoma sanguisuga, T. …

Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity

P Schwabl, J Maiguashca Sanchez, JA Costales… - PLoS …, 2020 - journals.plos.org
cruzi reference clones representing discrete typing units (DTUs) TcI, … Studies on the related,
Chagas disease parasite Trypanosoma cruzi, for … Karyotypic changes also arise during T. …

Discrete Typing Units of Trypanosoma cruzi Identified by Real-Time PCR in Peripheral Blood and Dejections of Triatoma infestans Used in Xenodiagnosis …

I Zulantay, G Muñoz, D Liempi, T Rozas, MJ Manneschi… - Pathogens, 2022 - mdpi.com
… infestans reduces the composition of T. … spinolai used for XD on wild and naturally infected
Octodon degus … cruzi, with spatial and temporal variations [49,50], thus maintaining the …

Assessing Trypanosoma cruzi Parasite Diversity through Comparative Genomics: Implications for Disease Epidemiology and Diagnostics

A Majeau, L Murphy, C Herrera, E Dumonteil - Pathogens, 2021 - mdpi.com
… major genetic lineages, or discrete typing units (DTUs), known as … genetic lineages and the
composition of parasite strains … new tests able to detect infections with the full diversity of T. …