… is triggered by food consumption (Figure 2). … gastric and intestinal system can impact oral
drug absorption, including fluctuations in the gastrointestinal pH, an increased gastrointestinal …

… -dependent), drug and formulation properties, or food-drug interactions. Clinical evidence …
drug pharmacokinetic variability is mounting: eg gastric pH and emptying time, small intestinal …

… of food on various elements in drug absorption, including change in stomach pH and gastric
… the performance of PBPK models to correctly predict the lack of pH-dependent DDI potential …

… of food to the stomach, the proximal part of the stomach or … the stomach, for efficient digestion
by other enzymes, the pH … the complete digestion of the meal during a single transit period. …

… characteristics of GI fluids such as bile salt concentrations, pH and osmolality can affect the
… [34] After the intake of a meal, the colonic motility in patients with UC in remission was similar …

… medication. This review provides an overview of GI tract properties in special populations
compared to healthy adults and discusses how drug absorption is affected by these conditions. …

… Here we present a review of some in vivo data on digestive lipases, gastric and intestinal
pH, and BA levels that are already available for humans at various ages and patients with …

… critical to oral drug absorption. … oral absorption landscape: (1) specific patient populations,
(2) regional differences in the gastrointestinal tract, (3) advanced formulations and (4) food…

… fasted conditions or taken with a meal to maximize drug absorption. … Models predicted
either no food effect or negative food effect, depending on the software used and the stomach pH …

… Food intake stimulates GI secretions including hormones … lower gastric pH, delay stomach
emptying and increase GI transit … stomach pH within minutes to hours, diet itself can change GI …