… hemoglobin (HbF) [14, 15]. After this protected period young … , one pediatric study assessing
fosmidomycin-clindamycin (FOS-CM) combination therapy in Mozambican children <3 years …

… studying fosmidomycin, of which six were pediatric studies and … As of February 2022, there
are no ongoing fosmidomycin … a trial of triple therapy using fosmidomycin, clindamycin and …

… 3-day regimen of fosmidomycin and clindamycin of 30 and 10 … to cure malaria in children
younger than 3 years [87,88]. … cure of malaria in 10/10 children (6–12 years) on day 14, and a …

… , predominantly in children under the age of five years [Citation3]. … on day 1 and reported 14
treatment failures with only one of those … with two antibiotics, clindamycin and fosmidomycin. …

… -clindamycin [14], artesunate-mefloquine [13], fixed-dose artesunate-pyronaridine [15] and
artesunate-fosmidomycin [… falciparum malaria in African children. The first randomized trial of …

… the traditional treatment of azithromycin + atovaquone and clindamycin + quinine, … 1-deoxy-D-xylulose
5-phosphate reductoisomerase (DXR) is a rate-limiting enzyme and fosmidomycin …

… essential metabolic pathways that drove that symbiosis [14,15], as well as a … fosmidomycin,
which demonstrated effective in vivo antimalarial activity when conjugated with clindamycin …

… has been a major milestone for the treatment of malaria (Box 1). Today, artemisinin-based …
-line treatment for Plasmodium falciparum malaria in virtually all endemic countries (Figure 1), …

… fosmidomycin has been demonstrated to be safe and efficacious as an antimalarial in combination
therapy with clindamycin … and children aged under 5 and offers time-limited (10 years) …

… (MEP) of isoprenoid biosynthesis represent potential targets for treating zoonotic staphylococci.
Here we demonstrate that fosmidomycin (FSM) inhibits the first step of the isoprenoid …