… mixture of Th1 and Th2 effector T cells plus Foxp3 + pTregs. … but significant symptoms of
autoimmune disease, suggestive of ‘… regulatory T cells are positively selected on natural self-…

… immune tolerance and preventing autoimmune diseases. … Some of these regulatory T cells
express Foxp3 but some do … reestablish Treg cell-mediated dominant self-tolerance. One of …

… , Foxp3 has emerged as a key regulator of immune tolerance … into neonatal scurfy mice
prevented autoimmune disease … autosomal dominant autoimmune lymphoproliferative disease, …

… Tregs have the ability to mediate immune tolerance, and … the induction of Foxp3 in CD4 +
CD25 − conventional T cells was … is the dominant mechanism by which Foxp3 was inhibited in …

… to further categorize human CD4 + FOXP3 + T cells into three … that FOXP3-expressing and/or
CD25 high CD4 + T cells … strategies for autoimmune diseases with regulatory T cell (T reg …

… Regulatory T cells (Tregs) are small subsets of CD4 T cells that play a central role in the
controlling of immune tolerance… birth resulted in severe autoimmune diseases, which could be …

… Expression of FOXP3 serves as a dominant regulatory … The role of foxp3 in modulating
immune tolerance was … an autoimmune disease by significantly lowering the Treg cell population …

… (Foxp3) mediate 60 peripheral immune tolerance both to self-… for induction of tolerance in
autoimmune disease 435 and … of FOXP3 into 437 naive CD25-CD45RO-CD4+ T cells results …

… The loss of function of Foxp3 leads to autoimmune disease in both … Peripheral immune
tolerance is crucial to preventing the … tolerance is a subset of CD4 + Foxp3 + T cells known as …

… and small intestine which confer immune tolerance to food- and … of activated CD4 + T cells
express low levels of Foxp3 which … as CD3 + CD4 + CD25 high CD127 low Foxp3 + cells (34). …