… rats,35 in rat models of inflammation and fibrosis,30 and in patients with COPD.24, 60
Inert fluorinated gas fractional ventilation mapping was first demonstrated in rat lungs with a …

… The utility of these methods to quantify ventilation defects in … dynamic ventilation and
perfusion imaging, employing 19F-MRI of … Fluorinated-gas magnetic resonance imaging FD-MRI …

… low signal in fluorinated gas ventilation imaging and optimize … *, apparent diffusion coefficient
and fractional ventilation. The … The focus of this thesis is imaging using inhaled inert gases, …

… the protocol incorporated rat lungs saturated with an inert fluorinated gas/oxygen … rat
models of inflammation and fibrosis disease [1] has suggested that the fractional ventilation maps …

… including fluorinated gas MRI, oxygen-enhanced MRI and free… of regional ventilation, fractional
ventilation mapping is able … Airway inflammation may also contribute to ventilation defects…

… on inhalation of different fractions of oxygen gas (typically … and pulse sequences for lung
19 F-Fluorinated gas MRI … caused by infection, chronic inflammation, and mucus plugging …

… uses in various animal models for a range of diseases. … -term prognosis; exaggerated
inflammation leads to loss of … different from the small disassembled fractions. In the following …

… HP 129Xe TOF pulse sequence is capable to map and measure perfusion quantitively was
… Similar to inert fluorinated gas MRI mentioned above, the obtained ventilation images can …

… in lungs becoming inflamed and failure of gas exchange and … ) and hyperpolarized gas
magnetic resonance imaging (MRI) are … binning maps to map and quantify pulmonary ventilation. …

… inert fluorinated gas (19F) MRI [17–19] to better understand various lung diseases. Our main
focus will be on 3He gas MRI of small animal models … of regional fractional-ventilation [23, …