… In almost one-half of patients, the side effects occurred within the first 12 months of treatment;
and in general, the frequency of imatinib side effects decreased over time in the majority (…

… imatinib + ara-c) or a single oral dose of imatinib 400 mg/day. Primary endpoints were
hematological and molecular responses at 3 months and cytogenetic responses … by frequency and …

… phenotyping results, we observed a clearly decreased frequency of both CD56 ++ NK cells
and … An overview of the statistical analysis of the frequencies of all immune subsets during …

… cytogenetic response, while for major molecular response at … study of imatinib versus
interferon-alfa and low-dose cytarabine (… Means were compared by the t test and frequencies by …

… with imatinib alone or imatinib plus cytarabine treatment [16]. … bone mass and increased
osteoclast frequency in IFNAR1−/− … better molecular response rates with imatinib plus PegIFNα-…

… the reverse transcription molecular response (RT-MR), and the molecular monitoring of
BCR::… of early molecular response by 3 and 6 months with major molecular response by 12 and …

… With the advent of the tyrosine kinase inhibitor (TKI) imatinib in … molecular response (DMR:
MR 4 , MR 4.5 , MR 5 ). Nevertheless, since cure is not possible at this time, lifelong molecular …

… In conclusion, imatinib induced deep molecular responses that … to only 22.1% with interferon-α
plus low-dose cytarabine, and was … (eg peginterferon alfa-2a, cytarabine, or hydroxyurea). …

… Interferon versus STI571 (IRIS) Study Group. Frequency of major molecular responses to
imatinib or interferon alfa plus cytarabine in newly diagnosed chronic myeloid leukemia. N Engl …

… is a strong correlation between the deepness of molecular response and the rate of DMR …
(strictly to undetectable for > 2 years) in a large cohort of CML patients treated with imatinib. …