Facts and new hopes on selective FGFR inhibitors in solid tumors
… FGFR1 is frequently amplified … -dependent kinases, PI3K signaling, and amplification with
high expression of IGF1R, HER2, and EGFR (22, 27), thus questioning the FGFR dependency …
high expression of IGF1R, HER2, and EGFR (22, 27), thus questioning the FGFR dependency …
[HTML][HTML] Comprehensive identification of FGFR1-4 alterations in 5 557 Chinese patients with solid tumors by next-generation sequencing
W Gu, J Yang, Y Wang, J Xu, X Wang, F Du… - American Journal of …, 2021 - ncbi.nlm.nih.gov
… common alterations, especially FGFR1 amplification (9.9%). … breast cancer and were
associated with endocrine therapy … from miR-99a-dependent inhibition and reinforcement of tumor …
associated with endocrine therapy … from miR-99a-dependent inhibition and reinforcement of tumor …
[HTML][HTML] Oncogene alterations in non-small cell lung cancer with FGFR1 amplification—novel approach to stratify patients who benefit from FGFR inhibitors
H Kitai, H Ebi - Translational Lung Cancer Research, 2024 - ncbi.nlm.nih.gov
… tail rearrangements within or close to the FGFR1 gene associated with FGFR1 dependency.
… These rearrangements led to an FGFR1-centered amplification pattern, and they frequently …
… These rearrangements led to an FGFR1-centered amplification pattern, and they frequently …
Clinical complexity of utilizing FGFR inhibitors in cancer therapeutics
SR Chandana, HM Babiker… - Expert Opinion on …, 2020 - Taylor & Francis
… of tumors in mice dependent upon FGFR1, FGFR2 and … Most common genetic alterations
are FGFR1 amplifications (40%), … and adrenocortical carcinoma with FGFR1 amplification. The …
are FGFR1 amplifications (40%), … and adrenocortical carcinoma with FGFR1 amplification. The …
Rare FGFR oncogenic alterations in sequenced pediatric solid and brain tumors suggest FGFR is a relevant molecular target in childhood cancer
L Lazo De La Vega, H Comeau, S Sallan… - JCO Precision …, 2022 - ascopubs.org
… of which also had an amplification. Activating alterations occurred most often in FGFR1 (n =
21… Three tumors from patients with fusion-positive RMS harbored focal FGFR4 amplifications: …
21… Three tumors from patients with fusion-positive RMS harbored focal FGFR4 amplifications: …
[HTML][HTML] Biological significance and targeting of the FGFR axis in cancer
AM Chioni, RP Grose - Cancers, 2021 - mdpi.com
… of FGF(R)s, their common irregularities in cancer and the … disease had FGFR1 amplification
that was associated with a … , FGFR activation-dependent cleavage of FGFR1 generates a C…
that was associated with a … , FGFR activation-dependent cleavage of FGFR1 generates a C…
Fibroblast growth factor receptors as treatment targets in clinical oncology
M Katoh - Nature reviews Clinical oncology, 2019 - nature.com
… Amplification of FGFR1 or FGFR2 occurs most frequently in patients with oestrogen … -dependent
mouse mammary tumour model 33 , furthermore, FGFR1 amplification is associated with …
mouse mammary tumour model 33 , furthermore, FGFR1 amplification is associated with …
[HTML][HTML] Rare FGFR oncogenic alterations in sequenced pediatric solid and brain tumors suggest FGFR is a relevant molecular target in childhood cancer
LL De La Vega, H Comeau, S Sallan… - JCO Precision …, 2022 - ncbi.nlm.nih.gov
… Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1
dependency in squamous cell lung cancer. Sci Transl Med 2:62ra93, 2010 [PMC free article] […
dependency in squamous cell lung cancer. Sci Transl Med 2:62ra93, 2010 [PMC free article] […
[HTML][HTML] Impact of fibroblast growth factor receptor 1 (FGFR1) amplification on the prognosis of breast cancer patients
R Erber, M Rübner, S Davenport, S Hauke… - Breast Cancer Research …, 2020 - Springer
… FGFR1 amplification occurs most frequently in patients with … (eg, multiplex ligation-dependent
probe amplification), a different … analyze the association between FGFR1 amplification and …
probe amplification), a different … analyze the association between FGFR1 amplification and …
[HTML][HTML] Biological and clinical implications of FGFR aberrations in paediatric and young adult cancers
LM Brown, PG Ekert, EDG Fleuren - Oncogene, 2023 - nature.com
… , FGFR1-amplified cell lines express higher levels of FGFR1 … that transform these same
cytokine-dependent cell lines [39, … frequently in brain tumours, with gain of FGFR1 being most …
cytokine-dependent cell lines [39, … frequently in brain tumours, with gain of FGFR1 being most …