[HTML][HTML] Omalizumab and IgE in the control of severe allergic asthma

Y Gon, S Maruoka, K Mizumura - Frontiers in pharmacology, 2022 - frontiersin.org
… the dose from IgE levels after initiating treatment from the study groups, and there is no
specific recommendation for revising the dosage of omalizumab from the manufacturer. …

[HTML][HTML] Omalizumab in IgE-mediated food allergy: a systematic review and meta-analysis

T Zuberbier, RA Wood, C Bindslev-Jensen… - The Journal of Allergy …, 2023 - Elsevier
… The current meta-analysis provided evidence of the efficacy of OMA in patients with IgE-mediated
FA and corroborates the findings from individual studies that OMA can enable …

Roles of omalizumab in various allergic diseases

Y Okayama, H Matsumoto, H Odajima… - Allergology …, 2020 - jstage.jst.go.jp
… of action and effectiveness of omalizumab against major IgE related diseases; adult and …
Omalizumab can actively dissociate IgE from FcεRI, albeit at concentrations higher than …

[HTML][HTML] The anti-IgE mAb omalizumab induces adverse reactions by engaging Fcγ receptors

B Balbino, P Herviou, O Godon… - The Journal of …, 2020 - Am Soc Clin Investig
… individual mice with bars indicating mean ± SEM pooled from 2 (FcγR null ; … omalizumab/IgE
ICs can activate neutrophils through engagement of FcγRs. We purified neutrophils from

[HTML][HTML] The mechanistic and functional profile of the therapeutic anti-IgE antibody ligelizumab differs from omalizumab

P Gasser, SS Tarchevskaya, P Guntern… - Nature …, 2020 - nature.com
… - and omalizumab-mediated IgE dissociation from FcεRIα on the … -IgE antibodies and antibody
fragments, we quantified IgE … presence of the respective anti-IgE antibody (Fig. 3c). Again, …

Evolution of our view on the IgE molecule role in bronchial asthma and the clinical effect of its modulation by omalizumab: Where do we stand today?

J Novosad, I Krčmová - International Journal of …, 2020 - journals.sagepub.com
… about the effects of omalizumab treatment which leads to … the very complex role of the IgE
molecule in the organism (with … from its modulation by targeted therapy with omalizumab are …

[HTML][HTML] IgE-mediated multimorbidities in allergic asthma and the potential for omalizumab therapy

M Humbert, J Bousquet, C Bachert, O Palomares… - The Journal of Allergy …, 2019 - Elsevier
IgE component presenting as multimorbidities with allergic asthma, and we discuss the
available evidence for anti-IgE therapy with omalizumab … We have presented the findings from a …

New insights into the utility of omalizumab

JC Cardet, TB Casale - Journal of Allergy and Clinical Immunology, 2019 - jacionline.org
Omalizumab binds IgE and prevents its engagement with FcεRIα, thereby downregulating …
contribution from recent studies on omalizumab has been the demonstration that omalizumab

Omalizumab and mast cell disorders: are we there yet?

CR Weiler - The Journal of Allergy and Clinical Immunology: In …, 2019 - jaci-inpractice.org
… By this mechanism, it secondarily reduces free IgE and IgE-mediated reactions. … omalizumab
might have some benefit in this population. The role(s) of and benefit(s) from omalizumab in …

[HTML][HTML] Pediatric usage of omalizumab: a promising one

L Yu, H Zhang, J Pan, L Ye - World Allergy Organization Journal, 2021 - Elsevier
Omalizumab is the first monoclonal antibody-based medicine used in … It binds to free IgE and
prevents it from binding to IgEOmalizumab can markedly reduce the level of circulating IgE