The exposome and toxicology: a win–win collaboration

R Barouki, K Audouze, C Becker, L Blaha… - Toxicological …, 2022 - academic.oup.com
… to exposome characterization is a needed framework for mechanistic understanding and …
This review considers the consequences of the development of the exposome concept on …

The exposome and health: Where chemistry meets biology

R Vermeulen, EL Schymanski, AL Barabási, GW Miller - Science, 2020 - science.org
… Large-scale exposome studies provide a systematic … adverse effects on health. If systematic
analysis reveals major … explore the mechanistic role of many other exposome chemicals …

[HTML][HTML] Unravelling the chemical exposome in cohort studies: routes explored and steps to become comprehensive

S Huhn, BI Escher, M Krauss, S Scholz… - Environmental Sciences …, 2021 - Springer
… Most exposome definitions acknowledge that typically only chemicals that enter the … or
organ functions and provoke adverse effects. Hence, the exposome can be described as the …

[HTML][HTML] Towards mass spectrometry-based chemical exposome: current approaches, challenges, and future directions

J Xue, Y Lai, CW Liu, H Ru - Toxics, 2019 - mdpi.com
… We review the current chemical exposome measurement … in implementing the concept
of chemical exposome and … the mechanistic basis of the exposome in an affordable way. …

Defining the scope of exposome studies and research needs from a multidisciplinary perspective

P Zhang, C Carlsten, R Chaleckis… - … science & technology …, 2021 - ACS Publications
… Moreover, experimental and observational studies evaluating adverse effects … for mechanistic
underpinnings for a charged claim related to social inequities driving adverse health effects

The metabolome: a key measure for exposome research in epidemiology

DI Walker, D Valvi, N Rothman, Q Lan… - Current Epidemiology …, 2019 - Springer
adverse effects [7, 8]. Both are enabled by computational power of big data and provide exciting
new opportunities for implementing the exposome into … into the underlying mechanism of …

The Exposome in toxicologic pathology

B Bolon, WM Haschek - Toxicologic Pathology, 2020 - journals.sagepub.com
… teams that assemble data sets for building AOP models, so in this respect toxicologic
pathologists are well positioned to participate in relating mechanistic data to the exposome. …

[HTML][HTML] The role of exposomes in the pathophysiology of autoimmune diseases I: toxic chemicals and food

A Vojdani, E Vojdani - Pathophysiology, 2021 - mdpi.com
… -related immune reactions is the oral tolerance mechanism, … in the pathophysiology of
chemical-induced autoimmunity [49,… lectins) that have a detrimental effect on both enterocyte and …

[HTML][HTML] Biomarkers of environmental toxicants: exposure and biological effects

RJ Turesky, K Lu - Toxics, 2020 - mdpi.com
… on mechanistic studies that examine the biological effects of … in implementing the concept
of chemical exposome and … is one of the key events in chemical-induced carcinogenesis. It is …

The contribution of the exposome to the burden of cardiovascular disease

T Münzel, M Sørensen, O Hahad… - Nature Reviews …, 2023 - nature.com
… are associated with adverse cardiovascular health effects such as … as the driver of the
detrimental effects of the exposome. … , the induced pathological and mechanistic changes in …