… Understanding chemical induced adducts using … a better understanding of the underlying
mechanistic pathways [32]. … the Exposome approach, which includes internal and external …

… on mechanistic studies that examine the biological effects of … in implementing the concept
of chemical exposome and … is one of the key events in chemical-induced carcinogenesis. It is …

… From the exposome to mechanistic understanding of chemical-induced adverse effects. …
exposures as contact events and reattributing the exposome to exclusively represent these …

… of delineating and understanding environmental hazards. The concept of the “exposome”
was … Despite previous proposal of mechanistic hypotheses aiming to explain the effect of air …

… data, combined with advanced in vitro and in vivo toxicological studies, can shed light on
the mechanistic pathways by which exposures lead to adverse health outcomes. This deepens …

… Acknowledging the impact of the exposome on human health, this … a mechanistic
understanding of the mode of action and … suggests that the detrimental effects that appear at doses …

… the internal exposome to contribute to health outcomes and how this mechanistic information
… Because of the lack of knowledge of their negative impacts and the limitations of current …

… literature pertaining to chemical-induced vitiligo. Thereafter, … chemicals involved in the
downstream mechanism of vitiligo; (iii) … Alternatively, to gauge the other adverse effects caused by …

… effects within the human body for effective intervention, risk mitigation or even treatment of
adverse effects… exposures through the understanding of toxicological mechanism [107] and …

… Overall, the concept of the exposome, which encompasses … mechanism of actions based
on new biomarkers of effect … a molecular initiating event and adverse effects (79, 80). In low…