… effects within the human body for effective intervention, risk mitigation or even treatment of
adverse effects. In … exposures through the understanding of toxicological mechanism [107] and …

… of the mechanistic connections between … understanding of the occupational exposome
can be of great value to unveil the pathogenic mechanisms of chemical-induced adverse effects …

… In fact, xenobiotic metabolism is the principal mechanism for … to attenuate or ideally eliminate
their harmful effects. … body, and to mitigate early harmful impacts in cells by the activation of …

… remain gaps in characterizing the exposome, as well as relating the exposome to measurements
of biological function to better understand the impacts of chemical exposures on human …

… exposome research with the AOP concept may facilitate a mechanistic understanding of
stress-induced adverse effects… from various components of the exposome, determine the primary …

… to have a strong evidence-based mechanistic knowledge linking molecular perturbations
and … From the exposome to mechanistic understanding of chemical-induced adverse effects …

… to mechanistically validated effect and susceptibility biomarkers in order to better understand
the … the presence of tangible adverse effects and may indicate converging effects of different …

… concept of the exposome has been developed [5]. With knowledge of beneficial and adverse
effects … Detoxification is a fundamental and essential component of the defense mechanism …

… evidence on chemical-induced adverse health effects that … mechanistic evidence can also
identify data gaps in the current understanding of how a chemical may cause adverse effects …

… main mechanisms of chemical-induced pathology in humans. … The concept of exposome has
been recently introduced, … with biomarker technologies, the exposome framework has been …