[HTML][HTML] Cellular and functional heterogeneity of the airway epithelium

JD Davis, TP Wypych - Mucosal immunology, 2021 - Elsevier
… with lung cancer mortality in smokers,46 and ablation of club cells in murine airways prevents
lung … Tuft cells have been noted in the airways of rodents,138 cows, and bulls.139 Recent …

Hyperoxia-induced bronchopulmonary dysplasia: better models for better therapies

K Giusto, H Wanczyk, T Jensen… - Disease Models & …, 2021 - journals.biologists.com
… from human or rodent lung tissues can be cultured together with lung-derived fibroblasts
or … This study demonstrates that functional lung assessments are associated with structural …

Rapid atrophy of cardiac left ventricular mass in patients with non‐small cell carcinoma of the lung

SMR Kazemi‐Bajestani, H Becher… - Journal of cachexia …, 2019 - Wiley Online Library
… In rodents implanted with tumours, cardiac muscle loss occurs to a … Rodents with cancer
also show progressive decline in left ventricular ejection fraction (LVEF) and diastolic function.2, …

[HTML][HTML] Pulmonary alveolar regeneration in adult COVID-19 patients

J Chen, H Wu, Y Yu, N Tang - Cell research, 2020 - nature.com
… in adult human lungs. In rodents, it takes a few weeks to regenerate the alveoli and restore
… on MRI-based assessment of lung microstructure and analyses of lung function. Our results …

[HTML][HTML] Cigarette smoke exposure and inflammatory signaling increase the expression of the SARS-CoV-2 receptor ACE2 in the respiratory tract

JC Smith, EL Sausville, V Girish, ML Yuan… - Developmental cell, 2020 - cell.com
… ), the SARS-CoV-2 receptor, in rodent and human lungs. Using single-cell sequencing data,
we … Furthermore, our work identifies ACE2 as an interferon-stimulated gene in lung cells, …

Vascular contributions to cognitive impairment and dementia (VCID): A report from the 2018 National Heart, Lung, and Blood Institute and National Institute of …

BV Zlokovic, RF Gottesman, KE Bernstein… - Alzheimer's & …, 2020 - Wiley Online Library
… than do humans, replicating results from rodents in a different experimental model would …
imaging techniques that can be used to characterize cerebral vasculature and flow or functional

[HTML][HTML] Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents

EL Blanchard, D Vanover, SS Bawage, PM Tiwari… - Nature …, 2021 - nature.com
… Once we observed Cas13 function and IAV RNA degradation in vivo, we then tested … weight
and lung viral RNA data. Although we observed only a modest decrease in lung viral load, …

[HTML][HTML] Clinical quantification of the integrin αvβ6 by [18F]FB-A20FMDV2 positron emission tomography in healthy and fibrotic human lung (PETAL Study)

PT Lukey, C Coello, R Gunn, C Parker… - … and Molecular Imaging, 2020 - Springer
… CVs across all rodent tissues were 39–58%; for the lung, the … on published
immunohistochemistry of lung biopsies from … in the lungs of subjects with IPF compared with lungs

Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans

FS Passini, PK Jaeger, AS Saab, S Hanlon… - Nature biomedical …, 2021 - nature.com
… To investigate how tendon cells (tenocytes) detect mechanical forces, we developed a
functional imaging system that enables simultaneous fluorescence microscopy and tissue …

Consequences of early postnatal lipopolysaccharide exposure on developing lungs in mice

AK Shrestha, ML Bettini, RT Menon… - … of Physiology-Lung …, 2019 - journals.physiology.org
… disrupts lung development by mechanisms that promote inflammation and prevent optimal
lung … The main function of the lungs is to promote effective gas exchange. To accomplish this …