… Citation13 Our results also revealed that all three EML4–ALK fusions presented after
resistance were the rare variant V5. The absence of common partners/variants in EGFR TKI–…

… receptor tyrosine kinase (RTK) oncogenic fusion proteins, that is… factors can also cause and
promote genomic instability. The … , which results in the presence of tyrosine kinase domain is …

… EML4-ALK fusion gene, resulting from the inversion of the short arm of the chromosome 2,
gives rise to the expression of a chimeric protein with the tyrosine kinase domain constitutively …

… The results of mutation analysis may help clinicians in the selection of other TKIs, since …
-ABL1 fusion protein induces genomic instability in CML stem cells and this instability contributes …

… results in the formation of chimeric X‑ALK fusion oncoproteins… tyrosine kinase inhibitors
(TKIs), drug resistance eventually develops via an adaptive secondary mutation in the ALK fusion …

… pathways resulting in microsatellite instability (MIN) or mutations. Genomic instability occurs
… In this review, new drugs targeting genomic instability and their mechanisms of action will …

… These authors elegantly demonstrated that the oncogenic BCR–ABL fusion gene, resulting
… inhibit DSB repair, block the BCR-ABL tyrosine kinase activity (STI571), or inhibit generation …

… myeloproliferative disease that is characterised by an abnormal fusion … The results of the
study revealed several kinds of D835 … to cause AML but induce a myeloproliferative disease in a …

… of tyrosine kinase inhibitors (TKIS) have been developed for EGFR mutations and ALK fusions
… Malfunction of cell cycle controls can result in genomic instability and the accumulation of …

… (when a genomic region is duplicated, resulting in fusion with a gene in the … to fusions
involving members of the FGFR tyrosine kinase family (FGFR1, FGFR2 and FGFR3) and its fusion …