[PDF][PDF] GPR84: an immune response dial?
ML Wojciechowicz, A Ma'ayan - Nature reviews. Drug discovery, 2020 - drive.google.com
… GLPG1250 is a potent and specific GPR84 antagonist6. Both PBI-4050 and GLPG1250 are
… for GPR84 modulators may emerge in the future, such as promoting immune responses in …
… for GPR84 modulators may emerge in the future, such as promoting immune responses in …
Targeting metabolic sensing switch GPR84 on macrophages for cancer immunotherapy
… Previous works have established that IFNβ augments anti-tumor immune response and
improve the efficacy of ICB [40, 54]. Taken together, we find it is plausible that the …
improve the efficacy of ICB [40, 54]. Taken together, we find it is plausible that the …
Evolutionary analyses reveal immune cell receptor GPR84 as a conserved receptor for bacteria-derived molecules
AS Schulze, G Kleinau, R Krakowsky, D Rochmann… - Iscience, 2022 - cell.com
… or lifestyle, including diet and associated microbial challenges for the immune system. To
address this hypothesis, GPR84 sequences of more than 200 vertebrate species (ortholog …
address this hypothesis, GPR84 sequences of more than 200 vertebrate species (ortholog …
Overcoming resistance to immunotherapy by targeting GPR84 in myeloid-derived suppressor cells
G Qin, S Liu, J Liu, H Hu, L Yang, Q Zhao, C Li… - … and Targeted Therapy, 2023 - nature.com
… Although the roles of MDSCs in promoting tumor growth and inhibiting immune response …
that GPR84 was exclusively overexpressed on MDSCs. It was further found that GPR84 was …
that GPR84 was exclusively overexpressed on MDSCs. It was further found that GPR84 was …
Discovery and characterization of novel antagonists of the proinflammatory orphan receptor GPR84
L Jenkins, S Marsango, S Mancini… - ACS Pharmacology & …, 2021 - ACS Publications
… of a broader range of high affinity GPR84 antagonists would be of considerable use in …
of GPR84. In early studies, we noted that these molecules were not active at mouse GPR84. …
of GPR84. In early studies, we noted that these molecules were not active at mouse GPR84. …
[HTML][HTML] The two formyl peptide receptors differently regulate GPR84-mediated neutrophil NADPH oxidase activity
J Mårtensson, M Sundqvist, A Manandhar… - … of Innate Immunity, 2021 - karger.com
… response mediated through GPR84 is in line with our earlier results [20]. The ROS production
profile mediated by GPR84 … 10 , that is, the response was induced rapidly upon agonist …
profile mediated by GPR84 … 10 , that is, the response was induced rapidly upon agonist …
Modulation of the G-protein-coupled receptor 84 (GPR84) by agonists and antagonists
LH Chen, Q Zhang, X Xie, FJ Nan - Journal of Medicinal …, 2020 - ACS Publications
… the innate immune system, including monocytes, macrophages, and neutrophils in the
periphery and microglia in the central nervous system. (9,10) In physiological conditions, …
periphery and microglia in the central nervous system. (9,10) In physiological conditions, …
20 years an orphan: is GPR84 a plausible medium-chain fatty acid-sensing receptor?
VB Luscombe, D Lucy, CJR Bataille… - DNA and Cell …, 2020 - liebertpub.com
… GPR84 is that of being a medium-chain fatty acid (MCFA) receptor. While MCFAs have been
shown to activate GPR84… time” free fatty acid receptor subtypes, GPR84 is not expressed by …
shown to activate GPR84… time” free fatty acid receptor subtypes, GPR84 is not expressed by …
[HTML][HTML] GRK2 selectively attenuates the neutrophil NADPH-oxidase response triggered by β-arrestin recruiting GPR84 agonists
J Fredriksson, A Holdfeldt, J Mårtensson… - … et Biophysica Acta (BBA …, 2022 - Elsevier
… β-arrestin recruiting GPR84 agonist was not … response relied, similar to the response
induced by FPR2 agonists, primarily on the actin cytoskeleton. In summary, we show that GPR84 …
induced by FPR2 agonists, primarily on the actin cytoskeleton. In summary, we show that GPR84 …
Selective phosphorylation of threonine residues defines GPR84–arrestin interactions of biased ligands
S Marsango, RJ Ward, L Jenkins, AJ Butcher… - Journal of Biological …, 2022 - ASBMB
… Consistent with this, an antiserum able to identify pSer 221 /pSer 224 recognized GPR84 …
recognized GPR84 after exposure to 2-HTP and not DL-175. Two distinct GPR84 antagonists …
recognized GPR84 after exposure to 2-HTP and not DL-175. Two distinct GPR84 antagonists …