Increased expression of galanin and its receptors in the dorsal hippocampus during epileptogenesis in a rat model of pilocarpine-induced temporal lobe epilepsy
J Sun, S Xu, X Li, T Li, C Liu, J Zhou, G Luan, Z Xu - Stress and Brain, 2023 - sciopen.com
… to identify the galanin receptor subtype (s) involved in this effect. In the present study, the
expression of galanin and that of its receptors in a rat model of temporal lobe epilepsy was …
expression of galanin and that of its receptors in a rat model of temporal lobe epilepsy was …
An assembly of galanin–galanin receptor signaling network
L Gopalakrishnan, O Chatterjee, C Raj… - Journal of Cell …, 2021 - Springer
… Galanin has a role in mediating food intake, memory, sexual behavior… epilepsy, diabetes
mellitus, and chronic pain. However, the understanding of signaling mechanisms of the galanin …
mellitus, and chronic pain. However, the understanding of signaling mechanisms of the galanin …
[HTML][HTML] Insights into potential targets for therapeutic intervention in epilepsy
C Zavala-Tecuapetla, M Cuellar-Herrera… - International journal of …, 2020 - mdpi.com
… (TRPV1) channel) and receptors (galanin and melatonin receptors). All of them have … seizures
but also in displaying neuroprotective activity and in modifying the progression of epilepsy. …
but also in displaying neuroprotective activity and in modifying the progression of epilepsy. …
Structural insights into galanin receptor signaling
W Jiang, S Zheng - Proceedings of the National Academy of …, 2022 - National Acad Sciences
… In addition to galanin, the endogenous galanin-like peptide (GALP) and spexin have … or
administration of galanin in the nervous system of animals suppresses seizure development and …
administration of galanin in the nervous system of animals suppresses seizure development and …
Galanin receptors as drug target for novel antidepressants
DG Demsie, BM Altaye, E Weldekidan… - … : Targets and Therapy, 2020 - Taylor & Francis
… physiological and pathological functions including epilepsy, chronic anxiety, depression…
receptors, namely Galanin receptor 1 (GalR1), Galanin receptor 2 (GalR2) and Galanin receptor …
receptors, namely Galanin receptor 1 (GalR1), Galanin receptor 2 (GalR2) and Galanin receptor …
Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability
NN Rieser, M Ronchetti, AL Hotz, SCF Neuhauss - bioRxiv, 2024 - biorxiv.org
… epileptic seizures, galanin exerts a sedative influence on the brain, primarily through the
galanin receptor … galanin's sedative effects, leading to overactivation of the brain and increased …
galanin receptor … galanin's sedative effects, leading to overactivation of the brain and increased …
Neural networks in generalized epilepsy and novel antiepileptic drugs
FM Werner, R Coveñas - Current pharmaceutical design, 2019 - ingentaconnect.com
… alterations of classical neurotransmitters (acetylcholine, dopamine, gamma-aminobutyric
acid (GABA), glutamate, noradrenaline, serotonin) and neuropeptides (neuropeptide Y, galanin…
acid (GABA), glutamate, noradrenaline, serotonin) and neuropeptides (neuropeptide Y, galanin…
Synergistic effects of the galanin analog 810–2 with the antiseizure medication levetiracetam in rodent seizure models
CS Metcalf, S Gagangras, G Bulaj, HS White - Epilepsia, 2022 - Wiley Online Library
… The neuropeptide galanin reduces seizures in several preclinical seizure and epilepsy models,
but its clinical … The lead galanin analog 810–2 is systemically bioavailable and reduces …
but its clinical … The lead galanin analog 810–2 is systemically bioavailable and reduces …
[HTML][HTML] Galanin analogs prevent mortality from seizure-induced respiratory arrest in mice
R Collard, MC Aziz, K Rapp, C Cutshall… - Frontiers in Neural …, 2022 - frontiersin.org
… seizures and downstream breathing control following seizures, and the depletion of galanin
may … It may also be that enhancement of galanin signaling in the amygdala protects against …
may … It may also be that enhancement of galanin signaling in the amygdala protects against …
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