Increased expression of galanin and its receptors in the dorsal hippocampus during epileptogenesis in a rat model of pilocarpine-induced temporal lobe epilepsy

J Sun, S Xu, X Li, T Li, C Liu, J Zhou, G Luan, Z Xu - Stress and Brain, 2023 - sciopen.com
… to identify the galanin receptor subtype (s) involved in this effect. In the present study, the
expression of galanin and that of its receptors in a rat model of temporal lobe epilepsy was …

An assembly of galaningalanin receptor signaling network

L Gopalakrishnan, O Chatterjee, C Raj… - Journal of Cell …, 2021 - Springer
Galanin has a role in mediating food intake, memory, sexual behavior… epilepsy, diabetes
mellitus, and chronic pain. However, the understanding of signaling mechanisms of the galanin

[HTML][HTML] Insights into potential targets for therapeutic intervention in epilepsy

C Zavala-Tecuapetla, M Cuellar-Herrera… - International journal of …, 2020 - mdpi.com
… (TRPV1) channel) and receptors (galanin and melatonin receptors). All of them have … seizures
but also in displaying neuroprotective activity and in modifying the progression of epilepsy. …

Structural insights into galanin receptor signaling

W Jiang, S Zheng - Proceedings of the National Academy of …, 2022 - National Acad Sciences
… In addition to galanin, the endogenous galanin-like peptide (GALP) and spexin have … or
administration of galanin in the nervous system of animals suppresses seizure development and …

Galanin

S Hirako - Handbook of Hormones, 2021 - Elsevier
Galanin (GAL) is a 29-aa peptide that was first discovered in the gut, and is widely expressed
in the central and peripheral nervous systems. GAL receptors (ie, GALR1, GALR2, and …

Galanin receptors as drug target for novel antidepressants

DG Demsie, BM Altaye, E Weldekidan… - … : Targets and Therapy, 2020 - Taylor & Francis
… physiological and pathological functions including epilepsy, chronic anxiety, depression…
receptors, namely Galanin receptor 1 (GalR1), Galanin receptor 2 (GalR2) and Galanin receptor

Guardian of Excitability: Multifaceted Role of Galanin in Whole Brain Excitability

NN Rieser, M Ronchetti, AL Hotz, SCF Neuhauss - bioRxiv, 2024 - biorxiv.org
epileptic seizures, galanin exerts a sedative influence on the brain, primarily through the
galanin receptorgalanin's sedative effects, leading to overactivation of the brain and increased …

Neural networks in generalized epilepsy and novel antiepileptic drugs

FM Werner, R Coveñas - Current pharmaceutical design, 2019 - ingentaconnect.com
… alterations of classical neurotransmitters (acetylcholine, dopamine, gamma-aminobutyric
acid (GABA), glutamate, noradrenaline, serotonin) and neuropeptides (neuropeptide Y, galanin

Synergistic effects of the galanin analog 810–2 with the antiseizure medication levetiracetam in rodent seizure models

CS Metcalf, S Gagangras, G Bulaj, HS White - Epilepsia, 2022 - Wiley Online Library
… The neuropeptide galanin reduces seizures in several preclinical seizure and epilepsy models,
but its clinical … The lead galanin analog 810–2 is systemically bioavailable and reduces …

[HTML][HTML] Galanin analogs prevent mortality from seizure-induced respiratory arrest in mice

R Collard, MC Aziz, K Rapp, C Cutshall… - Frontiers in Neural …, 2022 - frontiersin.org
seizures and downstream breathing control following seizures, and the depletion of galanin
may … It may also be that enhancement of galanin signaling in the amygdala protects against …