Gene signature and connectivity mapping to assist with drug prediction for pancreatic ductal adenocarcinoma
Y Xiao, B Zhang, JM Cloyd, G Xu, S Du, Y Mao… - Surgical Oncology, 2022 - Elsevier
Introduction The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is
highly variable and there is a paucity of effective treatment options for patients with PDAC.
Genome-wide analyses may allow for potential drugs to be identified using differentially
expressed genes, as well as constructing protein interaction networks and molecule-gene
connectivity mapping. Methods Microarray data of RNA expression profiling of PDAC and
normal pancreas tissues were downloaded from the Gene Expression Omnibus (GEO) …
highly variable and there is a paucity of effective treatment options for patients with PDAC.
Genome-wide analyses may allow for potential drugs to be identified using differentially
expressed genes, as well as constructing protein interaction networks and molecule-gene
connectivity mapping. Methods Microarray data of RNA expression profiling of PDAC and
normal pancreas tissues were downloaded from the Gene Expression Omnibus (GEO) …
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