[HTML][HTML] Generation of pure highly functional human anti-tumor specific cytotoxic T lymphocytes with stem cell-like memory features for melanoma immunotherapy

M Hamieh, JF Chatillon, E Dupel, F Bayeux… - Frontiers in …, 2021 - frontiersin.org
Adoptive immunotherapy based on the transfer of anti-tumor cytotoxic T lymphocytes (CTLs) …
are injected without further purification, along with autologous activated T cells of unknown …

[HTML][HTML] Increased antitumor efficacy of PD-1-deficient melanoma-specific human lymphocytes

…, JM Heslan, J Shaffer, T Beauvais… - … for Immunotherapy of …, 2020 - ncbi.nlm.nih.gov
… properties of T cells for adoptive cell transfer purposes. So far, … gene editing in virus-specific
cytotoxic T lymphocytes (CTL)23 24 … Sorting and amplification of Melan-A specific T cells was …

[HTML][HTML] Low avidity T cells do not hinder high avidity T cell responses against melanoma

K Ioannidou, O Randin, A Semilietof… - Frontiers in …, 2019 - frontiersin.org
… of target cells to high avidity cytotoxic T cells. The … avidity, whereby Melan-A-specific T cells
are frequently detectable … TILs are regularly used for adoptive T cell therapy which can lead …

[HTML][HTML] CD8 T cell function and cross-reactivity explored by stepwise increased peptide-HLA versus TCR affinity

P Baumgaertner, J Schmidt, CM Costa-Nunes… - Frontiers in …, 2022 - frontiersin.org
… the tumor cell recognition capacity of distinct cytotoxic T cells. … recognition in adoptive T
cell immunotherapy, T cells were … /ELA vaccine-derived Melan-A-specific clones, pooled data …

[HTML][HTML] Engineering a human plasmacytoid dendritic cell-based vaccine to prime and expand multispecific viral and tumor antigen-specific T-cells

…, K Laulagnier, JP Molens, H Benlalam, B Dreno… - Vaccines, 2021 - mdpi.com
… , which can be used in adoptive or active immunotherapy for the … Interestingly, an expansion
of Melan-A-specific T-cells was … , we cocultured them with CD8 + T-lymphocytes purified from …

Identification of novel cancer-specific T cell targets by dissection of successful tumour-infiltrating lymphocyte therapy

C Rius Rafael - 2019 - orca.cardiff.ac.uk
Background – T cell-based cancer immunotherapy has emerged as the biggest … the key
effector cells are cytotoxic CD8+ T cells, which can detect anomalies in the proteome of cells that …

[HTML][HTML] Enhanced T-cell priming and improved anti-tumor immunity through lymphatic delivery of checkpoint blockade immunotherapy

C Mantilla-Rojas, FC Velasquez, JE Morton… - Cancers, 2022 - mdpi.com
cytotoxic T-cells for anti-tumor immunity. Adoptive T-cell therapies use autologous T lymphocytes
… Nonetheless, we observed significant increases in Melan-A specific CD4 + and CD8 + …

High-throughput screening of human tumor antigen–specific CD4 T cells, including neoantigen-reactive T cells

C Costa-Nunes, A Cachot, S Bobisse, M Arnaud… - Clinical Cancer …, 2019 - AACR
… The CD4 T-cell library method (17) was adopted with the aim … Purified CD4 T cells were
sorted according to the naïve … the ex vivo detection of Melan-Aspecific CD4 T cells in HLA-DQ6 …

Usefulness of IL-21, IL-7, and IL-15 conditioned media for expansion of antigen-specific CD8+ T cells from healthy donor-PBMCs suitable for immunotherapy

JA Chamucero-Millares, DA Bernal-Estévez… - Cellular …, 2021 - Elsevier
… research on the adoptive transfer of T cells to restore the antigen… and stDCs with purified
CD8+ T cells clones specific for … that the expansion of Melan-A-specific CD8+ T cell-driven by …

Immunological effects of isolated regional perfusion in malignant melanoma

J Johansson - 2019 - gupea.ub.gu.se
… Another common classification of immune cells purified from … CD4 for helper T cells and
CD8 for cytotoxic T cells. … In adoptive cell transfer (ACT) T cells are recovered from the patient, …