… and re-establishment of DNA methylation in embryonic, germline … into DNA methylation
gained from studying genetic diseases. … of recruiting the DNA methylation machinery to ensure …

… diseases, immunological diseases, atherosclerosis, and osteoporosis. In this review, I
discuss DNA hypermethylation in disease and … disruption of the epigenetic machinery [Citation56], …

… mutated in these diseases have all been implicated in tumorigenesis, and it is probably
that genetic disorders of the epigenetic machinery create an environment of cancer …

… Moreover, a subset of TFs that possess the ability to rearrange the epigenome (so-called
pioneer TFs) are able to interact with the epigenetic machinery, altering the DNA methylation …

… A central question in the field is how DNA methylation machineries interact with other …
DNA‐modifying enzymes implicated in human diseases (Hansen et al, 1999). Genetic alterations …

… disease onset and progression. In this review, we summarize recent milestones in characterizing
the human genetic basis of DNA methylation … , or even machine learning approaches …

… with DNA methylation and post-transcriptional modifications … of the transcriptional machinery
to modulate gene expression. … of human disease. The most well established therapies alter …

… sequences or gene bodies. As the predominant promoter element for constitutively expressed
housekeeping genes, CGIs are frequently enriched for transcriptional initiation machinery, …

… changes such as DNA methylation, histone modification, and noncoding RNAs. DNA
methylation machinery … disorders, including many sporadic and hereditary disorders, are …

… Not surprisingly, aberrant DNA methylation is a feature of many … and genetic defects in
components of the DNA methylation machinery have been linked to human congenital disease [6]. …