Genetic and immunologic evaluation of children with inborn errors of immunity and severe or critical COVID-19
Background Most severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected
individuals are asymptomatic or only exhibit mild disease. In about 10% of cases, the
infection leads to hypoxemic pneumonia, although it is much more rare in children. Objective
We evaluated 31 young patients aged 0.5 to 19 years who had preexisting inborn errors of
immunity (IEI) but lacked a molecular diagnosis and were later diagnosed with coronavirus
disease 2019 (COVID-19) complications. Methods Genetic evaluation by whole-exome …
individuals are asymptomatic or only exhibit mild disease. In about 10% of cases, the
infection leads to hypoxemic pneumonia, although it is much more rare in children. Objective
We evaluated 31 young patients aged 0.5 to 19 years who had preexisting inborn errors of
immunity (IEI) but lacked a molecular diagnosis and were later diagnosed with coronavirus
disease 2019 (COVID-19) complications. Methods Genetic evaluation by whole-exome …
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