… activity (13). The authors of that study thus described a model in which inactivation of NUPR1
in pancreatic cancer … revealing a tumour suppressor role for NUPR1 in breast cancer and …

… antagonizes the growth of pancreatic cancer as well as several … Finally, we describe the
mechanism of function of such a … displays its anticancer activity via targeting NUPR1, we have …

… isoform of cytochrome P450 (CYP2E1) activity as part of a self-… In pancreatic cancer, NUPR1
can be activated by glucose … suggested that NUPR1 also works as a tumor suppressor by …

… the activity of the ferroptosis inducer erastin and worsens pancreatitis, in suitable mouse
models. … 5g), indicating that ZZW-115 bound NUPR1 possesses dominant negative activity or, in …

… formation in pancreatic cancer cells, we inactivated NUPR1 by … acted as a negative dominant
of the endogenous NUPR1 … Importantly, we show that inhibiting NUPR1 activity, by using …

… [5]; (ii) suppression of the GPX4 activity which prevents GSH-… phase of pancreatitis [11].
Then, it has been shown that … ratio and GPX4 activity and expression of key genes involved in …

… In conclusion, inactivation of NUPR1 induces a … acute phase of pancreatitis 7 . Then, it
has been shown that … that NUPR1 acts as an inhibitor of the PARP1 activity and its …

… Inactivation of wild type (WT) TP53 activity has direct effects on … ; in contrast, when the cells
were transfected with a dominant … Suppression of NUPR1 or LNC2 worsened pancreatitis in …

… -Cas9 loss-of-function screen targeting direct/indirect ERK … We conclude that concurrent
DDR suppression enhances … target for blocking KRAS oncogenic activity. Potent and selective …

… LONP1 serves as a suppressor activated by the Nrf2/Keap1 … Inactivation of the NUPR1 gene
has a conspicuous inhibitory … the activity of System Xc- (Table 1). It promotes ferroptosis of …