Lung function reflects the ability of the respiratory system and is utilized for the assessment
of respiratory diseases. Because type 2 airway inflammation influences lung function,
genome wide association studies (GWAS) for lung function would be improved by
adjustment with an indicator of the inflammation. Here, we performed a GWAS for lung
function with adjustment for exhaled nitric oxide (FeNO) levels in two independent Japanese
populations. Our GWAS with genotype imputations revealed that the RNF5/AGER locus …

RATIONALE: Lung function reflects the ability of the respiratory system and is utilized for the
assessment of respiratory diseases. Because type 2 airway inflammation influences lung
function, genome wide association studies (GWAS) for lung function would be improved by
adjustment with an indicator of the inflammation. Here, we performed a GWAS for lung
function with adjustment for exhaled nitric oxide (FeNO) levels in two independent Japanese
populations. We also performed a GWAS for FeNO to explore genetic factors related to …