Molecular pathogenesis, targeted therapies, and future perspectives for gastric cancer

Y Zeng, RU Jin - Seminars in cancer biology, 2022 - Elsevier
We will then review the molecular subtypes of gastric cancer to highlight the diversity seen
in this disease. We … gastric cancer mouse models as tools to study gastric cancer molecular …

Colorectal cancer in inflammatory bowel diseases: epidemiology and prevention: a review

E Marabotto, S Kayali, S Buccilli, F Levo, G Bodini… - Cancers, 2022 - mdpi.com
Colorectal cancer (CRC) is one of the most serious potential complications of inflammatory
bowel diseases (IBDs). The aging of patients affected by IBDs makes this issue a challenge …

Screening for colorectal cancer: US Preventive Services Task Force recommendation statement

KW Davidson, MJ Barry, CM Mangione, M Cabana… - Jama, 2021 - jamanetwork.com
… The benefit of reducing colorectal cancer deaths by screening for colorectal cancer in adults
50 … The USPSTF appreciates the various perspectives that were shared. Although future

Current progress and future perspectives of neoadjuvant anti-PD-1/PD-L1 therapy for colorectal cancer

Z Yang, G Wu, X Zhang, J Gao, C Meng, Y Liu… - Frontiers in …, 2022 - frontiersin.org
… , we focus on the development of neoadjuvant anti-PD-1/PD-L1 therapy and discuss the future
perspectivesWe should fully recognize the broad application prospect of immunotherapy …

Beyond microsatellite instability: evolving strategies integrating immunotherapy for microsatellite stable colorectal cancer

F Pecci, L Cantini, A Bittoni, E Lenci, A Lupi… - … Treatment Options in …, 2021 - Springer
… study in both gastric and colorectal cancer cohorts. Thirty-six percent of ORR was observed
in the CRC cohort alone with 7.9 mPFS in pMMR tumors. Phase II REGOMUNE trial [98] with …

Microsatellite instability in colorectal cancer liquid biopsy—current updates on its potential in non-invasive detection, prognosis and as a predictive marker

FYF Tieng, N Abu, LH Lee, NS Ab Mutalib - Diagnostics, 2021 - mdpi.com
… For example, a data analysis from 17 separate trials in the Adjuvant Colon Cancer End
Points (ACCENT) database had proven the potential of MSI status in predicting the outcomes/…

The intestinal microbiota and colorectal cancer

Y Cheng, Z Ling, L Li - Frontiers in immunology, 2020 - frontiersin.org
… with both spontaneous and chemically induced colon tumorigenesis. For example, … intestinal
tumors due to a mutation in the adenomatous polyposis coli (APC) tumor-suppressor gene

A potential role of IL-6/IL-6R in the development and management of colon cancer

M Turano, F Cammarota, F Duraturo, P Izzo… - Membranes, 2021 - mdpi.com
… In this review, we aim to shed light on the role of IL-6 signaling pathway alterations in sporadic
colorectal cancer and the development of familial polyposis syndrome. Furthermore, we

Impact of genetic mutations and nutritional status on the survival of patients with colorectal cancer

MAV Cavagnari, TD Silva, MAH Pereira, LJ Sauer… - Bmc Cancer, 2019 - Springer
… The carcinogenesis, survival and prognostic of colorectal cancer patients can be influenced
by genetic mutations and nutritional status Those process involves interactions among …

Mouse models for application in colorectal cancer: understanding the pathogenesis and relevance to the human condition

C Li, HCH Lau, X Zhang, J Yu - Biomedicines, 2022 - mdpi.com
in colon tumorigenesis. Consistently, preclinical studies reported that Apc mutation can induce
spontaneous formation of colon tumors in … used for research on colon tumorigenesis [6]. …