… Neural tube defects arise early in human embryogenesis when the neural tube, the precursor
to the brain and spinal cord, fails to properly close during neurulation. Failure to complete …

… Here, we discuss current understanding of human NTD genetics, recent advances regarding
… phenotypes for a greater appreciation of the developmental and genetic causes of NTDs. …

… the most rostral anterior portion of the developing neural tube, while the spinal cord originates
… Failure during neural tube closure can occur in different regions during the developmental …

… has been reported for neural tube defects, possibly because of a sex-related genetic or
epigenetic effect. Despite the decades long attempts to elucidate genetic factors causative of …

… for open neural tube defects (ONTD). … of neural tube defects, 5 advances in first and second
trimester prenatal ultrasound for the identification and characterization of neural tube defects …

… A large number of genetic studies in human NTDs have … picture of the complete genetic
architecture of these defects. The … to dissect the complex genetics of NTDs. The ultimate goal is to …

… Animal models can help uncover the intersections between genetic and environmental risk
factors to … NTDs are a multifactorial disorder with complex etiology involving both genetic and …

… the Neural Tube Defects (NTD's) through prenatal detection. The Neural Tube Defects are
a … malformations in the sense that one of these defects is present in every 500 births in the …

… Other PCP genes, and PCP effector and regulator genes also play a potential role in
convergent extension movements and neural tube closure (NTC), and therefore need to be further …

Neural tube defects (NTDs) remain among the most common types of congenital anomalies,
although prevalence rates at birth of these defects have been declining in certain areas of …