… alleles were strongly determined by genetics, although with a varying ethnic … for Lp(a) level
in Africans versus Caucasians. Thus, the LPA locus explained almost all of the total genetic …

… in the genetics of the LPA gene, risk categories of elevated … Black, 1,047 White, and 603
Hispanic individuals), the distribution of the major apo(a) isoform reflects the global population …

… the characteristic apolipoprotein(a)(apo(a)). Lp(a) occurs as a quantitative genetic trait with
… The major gene controlling the quantitative Lp(a) trait is LPA which codes for apo(a). Two …

… and people of African descent but little or no data exists on the influence of these factors on
lipid levels in indigenous black African populations. … environmental and genetic factors that …

… Therefore, unless homozygous for two LPA genes of identical KIV-2 repeat number, most
people have two different isoforms of apo(a). A person with two large isoforms may have low …

… Lp(a) concentrations are particularly dependent on Apo A … associated with smaller Apo A
isoforms and higher Lp(a) … risks are not linked to genetic variation in LPA at SNPs rs6415084, …

… of the genetic size polymorphism of apo(a)which … Africa and from Gabon demonstrated that
the LPA locus is the major locus determining Lp(a) levels also in autochthonous populations …

… Insight into the genetics of Lp(a) is progressing … Africa and from Gabon demonstrated that
the LPA locus is the major locus determining Lp(a) levels also in autochthonous populations …

… While Lp(a) is exclusively expressed in the liver and native tissue is hard to obtain in … apo(a)
isoforms and rs10455872 genotype. This exemplifies the intricate genetic architecture of Lp(…

… descent, but not resident in Africa, and thus genes chosen may not be appropriate for
indigenous African populations. Furthermore, only eight genes were included in the study and …