Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer's disease

J Stevenson-Hoare, A Heslegrave, G Leonenko… - Brain, 2023 - academic.oup.com
… a genome-wide association study for association of disease … Genome-wide association
studies (GWAS) of CSF … for clinical AD diagnosis in our cohort (over and above commonly used …

[HTML][HTML] Microglial activation, tau pathology, and neurodegeneration biomarkers predict longitudinal cognitive decline in Alzheimer's disease continuum

YH Chen, RR Lin, HF Huang, YY Xue… - Frontiers in Aging …, 2022 - frontiersin.org
… in cerebrospinal fluid (CSF) and plasma to predict longitudinal cognition status using
Alzheimer’s Disease Neuroimaging Initiative (ADNI) cohort. … in genome-wide association studies

Identifying potential genetic epistasis implicated in Alzheimer's disease via detection of SNP-SNP interaction on quantitative trait CSF Aβ42

J Li, D Chen, H Liu, Y Xi, H Luo, Y Wei, J Liu… - Neurobiology of …, 2024 - Elsevier
… Although genome-wide association studies have identified … genome-wide SNP-SNP interaction
on cerebrospinal fluid Aβ 42 … a genome-wide epistasis detection study in the ADNI cohort

Connecting dementia risk loci to the CSF proteome identifies pathophysiological leads for dementia

LM Reus, IE Jansen, BM Tijms, PJ Visser, N Tesi… - Brain, 2024 - academic.oup.com
Genome-wide association studies have successfully … AD CSF biomarkers (Aβ42, t-tau, p-tau
and t-tau/ Aβ42 ratio) … validation cohorts (ADC cohort: 4 rs4637258, P = 0.01; ADNI cohort

A GPU-based approach for detecting genome-wide SNP-SNP interactions of quantitative trait in ADNI cohorts

Q Zhang, H Liu, L Ao, H Liang… - 2022 IEEE International …, 2022 - ieeexplore.ieee.org
… The phenotype used in this paper is CSF Qt. Using … the variance explained by interaction
term on T-tau/Aβ42. The … ., “Genome-wide association and interaction studies of CSF

Blood and cerebrospinal fluid biomarkers for Alzheimer's disease: from clinical to preclinical cohorts

A Keshavan - 2019 - discovery.ucl.ac.uk
… contribution to AD risk was identified by genome-wide … Later studies have shown that the
CSF Aβ42/40 ratio may be … of rates of change of CSF biomarkers in ADNI. Reproduced with …

Associations of alcohol consumption with cerebrospinal fluid biomarkers of Alzheimer's disease pathology in cognitively intact older adults: the CABLE study

ZT Wang, KY Li, CC Tan, W Xu… - Journal of …, 2021 - content.iospress.com
… AD biomarkers, we examined the interaction effects (… higher biomarker ratios (CSF pTau/Aβ
42 , p = 0.0066; CSF tTau/… of drinking and CSF AD biomarkers (p-tau/Aβ42 and t-tau/Aβ42) (…

Key inflammatory pathway activations in the MCI stage of Alzheimer's disease

JA Pillai, S Maxwell, J Bena, LM Bekris… - Annals of Clinical …, 2019 - Wiley Online Library
… both cohorts and correlated with AD biomarkers (CSF Aβ42, … .3, 10, 11 In addition,
genome-wide association studies have … Subject demographics of the discovery and ADNI cohorts

Association of rs2072446 in the NGFR gene with the risk of Alzheimer's disease and amyloid‐β deposition in the brain

CY He, ZT Wang, YY Shen, AY Shi… - CNS Neuroscience …, 2022 - Wiley Online Library
Genome-wide association studies (GWAS) have identified more than 50 genetic risk factors
… study on the genome-wide network-based pathway analysis of CSF t-tau/Aβ42 ratio in the …

[PDF][PDF] Exploring brain structure and blood metabolic profiles using Alzheimer's pathway specific polygenic risk scores

J Harrison - 2021 - core.ac.uk
… by two large population cohort studies, the Avon Longitudinal … E (APOE), genome wide
association studies (GWAS) have … MRI techniques with cerebrospinal fluid and neuroradiology …