Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

L Core, K Adelman - Genes & development, 2019 - genesdev.cshlp.org
paused Pol II, nucleosomes as obstacles to elongation, and potential roles of pausing in
defining the precision and dynamicsInteraction with the NELF complex constrains paused Pol II

Regulation of promoter proximal pausing of RNA polymerase II in metazoans

R Dollinger, DS Gilmour - Journal of molecular biology, 2021 - Elsevier
… the pause and governing the dynamics of pause stability and … that relies on the interplay
between intrinsic and extrinsic … A later genome-wide analysis of promoter elements in the …

TFIID enables RNA polymerase II promoter-proximal pausing

CB Fant, CB Levandowski, K Gupta, ZL Maas, J Moir… - Molecular cell, 2020 - cell.com
… To circumvent these issues, we sought to reconstitute RNAPII promoter-proximal pausing
Genome-wide dynamics of Pol II elongation and its interplay with promoter proximal pausing

Genome-wide analyses of chromatin interactions after the loss of Pol I, Pol II, and Pol III

Y Jiang, J Huang, K Lun, B Li, H Zheng, Y Li, R Zhou… - Genome biology, 2020 - Springer
… Blocking of the transcription elongation enhances Cohesin … indicated that Pol II transcription
restrains the dynamics of … the Pol I-, Pol II-, and Pol III-binding and interaction hotspots …

NELF regulates a promoter-proximal step distinct from RNA Pol II pause-release

Y Aoi, ER Smith, AP Shah, EJ Rendleman, SA Marshall… - Molecular cell, 2020 - cell.com
… NELF functioning in early elongation complexes distinct from RNA Pol II pause-release. …
Despite the pervasiveness of promoter-proximal pausing in metazoans and the abundant …

Causes and consequences of RNA polymerase II stalling during transcript elongation

M Noe Gonzalez, D Blears, JQ Svejstrup - Nature reviews Molecular …, 2021 - nature.com
… for the maintenance of Pol II promoter-proximal pausing 53 , … interplay between
promoter-proximal pausing and pausing at … Advances in genome-wide Pol II mapping techniques …

A role for FACT in RNA polymerase II promoter-proximal pausing

TT Tettey, X Gao, W Shao, H Li, BA Story… - Cell reports, 2019 - cell.com
… ends of genes via Pol II that has been phosphorylated on Ser5 of its carboxy-terminal domain
(… through interaction with elongating Pol II phosphorylated on Ser2 of its CTD by the pause-…

RNA polymerase II dynamics shape enhancer–promoter interactions

G Barshad, JJ Lewis, AG Chivu, A Abuhashem… - Nature …, 2023 - nature.com
… Notably, promoter-proximal paused Pol II itself partially … We extended our work genome-wide
using data from a CRISPRi … report that Pol II contributes to enhancer–promoter interaction

Promoter-proximal regulation of gene transcription: key factors involved and emerging role of general transcription factors in assisting productive elongation

S Pal, D Biswas - Gene, 2023 - Elsevier
… regulation, promoter-proximal pausing of Pol II and its well-… a genome-wide stalling of Pol
II at the promoter-proximal sites … showed its interaction with DSIF and Pol II, however, it did …

RNA polymerase II pausing in development: orchestrating transcription

A Abuhashem, V Garg… - Open Biology, 2022 - royalsocietypublishing.org
… RNA polymerase II promoter-proximal pausing (Pol II pausing… of transcriptionally engaged
Pol II genome-wide at single base … Pol II pausing via a direct or indirect interaction with the …