[HTML][HTML] Reduced CpG island methylation of the TBC1D8 gene may predict risk for osteoporosis in Chinese postmenopausal women

QQ Ma, L Lin, Q Yao, J Yang, Y Hu, JB Yu - Oncotarget, 2020 - ncbi.nlm.nih.gov
… Caucasian women and 3657 men revealed that 2q 11.2 of … genome wide methylation in
bone cells from the femoral head … hip osteoarthritis [13]. Another article demonstrated that the …

Epigenetic mechanisms of aging and aging-associated diseases

A la Torre, F Lo Vecchio, A Greco - Cells, 2023 - mdpi.com
… Recently, genome-wide epigenetic studies have revealed … by the femoral heads of patients
with osteoarthritis (OA) or … patients displays differentially methylated regions in comparison …

Epigenetics in bone and joint disorders

N Altorok, V Nagaraja, B Kahaleh - Medical Epigenetics, 2021 - Elsevier
… performed a genome-wide DNA methylation profiling in T and … with differential methylation
patterns between bone samples … and nonfractured controls with osteoarthritis. There was a …

Rheumatoid arthritis and osteoporosis: shared genetic effect, pleiotropy and causality

XH Yu, YQ Yang, RR Cao, MK Cai… - Human molecular …, 2021 - academic.oup.com
… Overall, our study reveals complex genetic mechanism … Osteoporosis is a systemic bone
disease characterized by … that satisfied a genome-wide significance threshold of P < 5E-8 for …

[HTML][HTML] Recent advances in the genetics of fractures in osteoporosis

F Koromani, K Trajanoska, F Rivadeneira… - Frontiers in …, 2019 - frontiersin.org
… with bone fragility including familial forms of osteoporosis, … The first genome-wide
association study for radiographic … An inventory of the GWAS catalog in 2009 revealed that 88% …

[HTML][HTML] NELL-1 in genome-wide association studies across human diseases

X Cheng, J Shi, Z Jia, P Ha, C Soo, K Ting… - The American Journal of …, 2022 - Elsevier
… of NELL1 in diseases and treatments revealed by GWASs. … NELL-1 has therapeutic potential
in osteoarthritis due to its pro-… Osteoporosis is an aging-related bone-degenerative disease …

Discovery of potential biomarkers for osteoporosis diagnosis by individual omics and multi-omics technologies

J Yang, J Wu - Expert Review of Molecular Diagnostics, 2023 - Taylor & Francis
Osteoporosis (OP) is a systemic skeletal disease … rare variants obtained from genome wide
sequencing to complex … The hub differentially expressed genes with differential methylation

[HTML][HTML] The essential roles of m6A modification in osteogenesis and common bone diseases

Y Gu, Y Song, Y Pan, J Liu - Genes & Diseases, 2024 - Elsevier
… worldwide, bone-related diseases such as osteoporosis, osteoarthritis, and bone defects …
Studies have revealed that m 6 A could not only adjust the differentiation capacity of MSCs …

Skeletal aging and osteoporosis: mechanisms and therapeutics

A Chandra, J Rajawat - International journal of molecular sciences, 2021 - mdpi.com
… to a senescence profile in an aged skeleton and how bone … A genome-wide methylation
analysis among osteoporotic … post-menopausal osteoporosis and osteoarthritis, with superior …

[HTML][HTML] Knockout and Double Knockout of Cathepsin K and Mmp9 reveals a novel function of Cathepsin K as a regulator of osteoclast gene expression and bone …

G Zhu, W Chen, CY Tang, A McVicar… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
… using an unbiased genome-wide approach, ATAC-Seq profiling was performed using WT,
Ctsk -… OVX mediated osteoporosis, the DKO's effect on blocking osteoporosis was significantly …