The role of DNA methylation in gene regulation

PA Bommarito, RC Fry - Toxicoepigenetics, 2019 - Elsevier
… , including proteins that mediate a link between DNA methylation and the … DNA methylation
is written onto the genome by two … to erase the imprinting marks from the parental genomes. …

Mediation analysis supports a causal relationship between maternal hyperglycemia and placental DNA methylation variations at the leptin gene locus and cord blood …

V Gagné-Ouellet, E Breton, K Thibeault… - International Journal of …, 2020 - mdpi.com
… as the first 5 principal components as it was sufficient to bring genomic inflation close to 1 [28].
… made it possible to document the potential temporal stability of the reported DNAm marks

DNA methylation as a mediator of associations between the environment and chronic diseases: A scoping review on application of mediation analysis

R Fujii, S Sato, Y Tsuboi, A Cardenas, K Suzuki - Epigenetics, 2022 - Taylor & Francis
… epidemiological research applying mediation analyses. We … for the mediation analysis
using DNAm levels. However, we found heterogenous methods and interpretations in mediation

Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference

PJ Hop, R Luijk, L Daxinger, M Van Iterson, KF Dekkers… - Genome biology, 2020 - Springer
… that have widespread effects on DNA methylation, eg, NFKBIE, … mechanisms underlying
their effect on DNA methylation. … /or marks the transcriptional potential of a genomic region [5]. …

Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function

JS Hawe, R Wilson, KT Schmid, L Zhou… - Nature …, 2022 - nature.com
… We first carried out a genome-wide association study (GWAS) of DNA methylation in peripheral
blood, … Our results thus identify UBASH3B as a potential mediator of both genetic and …

DNA methylation: a potential mediator between air pollution and metabolic syndrome

P Poursafa, Z Kamali, E Fraszczyk, HM Boezen… - Clinical …, 2022 - Springer
… , we found that DNA methylation in neonatal blood is genome-wide significantly associated
… Studying these epigenetic marks together with their interplay with non-protein coding RNA …

Enhancer DNA methylation: implications for gene regulation

A Angeloni, O Bogdanovic - Essays in biochemistry, 2019 - portlandpress.com
… 5mC is widespread in vertebrate genomes where it is … that CTCF can mediate active DNA
demethylation at bound … consequence of this mark in certain genomic contexts remains …

DNA methylation and regulation of gene expression: Guardian of our health

GA Dhar, S Saha, P Mitra, R Nag Chaudhuri - The Nucleus, 2021 - Springer
… , the DNA methylation pattern in the genome undergoes … a stable epigenetic mark, DNA
methylation is actually labile … by vitamin intake other than through mediation by DNMTs or TETs? …

Genetic impacts on DNA methylation: research findings and future perspectives

S Villicaña, JT Bell - Genome biology, 2021 - Springer
… However, growing evidence now shows that genetic variation also plays a role in the
establishment of DNA methylation marks, independently of or in contribution with environmental …

Role of DNA methylation in mediating genetic risk of psychiatric disorders

A Starnawska, D Demontis - Frontiers in Psychiatry, 2021 - frontiersin.org
genome to mediate the risk of psychiatric disorders. The aim of this review is to explore the
putative role of DNA methylation … regulatory regions, epigenetic marks, and genes important …